不同剂量来曲唑用于多囊卵巢综合征患者促排卵的有效性及安全性研究

目的：对多囊卵巢综合征患者采用不同剂量的来曲唑药物治疗措施,探讨其对患者促排卵的临床有效性及安全性。方法方便抽取该院2014年9月—2016年3月收治的120例多囊卵巢综合征患者作为研究对象,依据数字表法将其随机分为3组,每组40例。其中一组采用2.5 mL的来曲唑,设为A组；一组采用5.0 mL的来曲唑,设为B组；一组采用7.5 mL的来曲唑,设为C组。分别对3组患者进行不同剂量的药物治疗措施,并观察治疗后患者的促排卵改善情况。结果 A组患者的总有效率为82.5%,B组为92.5%,C组为97.5%,A组与C组相比差异具有统计学意义(P<0.05)；A组的妊娠率以及排卵率均明显低于C组,组间比较差异具有统计学意义(P<0.05)。结论对多囊卵巢综合症患者应用较高剂量的来曲唑可有效促进排卵,提高了妊娠率,且安全可靠,值得推广。

Study on the Efficacy and Safety of Different Doses of the Different Doses of the Used for Ovulation Induction in Women with Polycystic Ovary Syn-drome

Objective Polycystic ovary syndrome were treated with different doses of letrozole azole drug treatment mea-sures, wrought iron investigate the clinical efficacy and safety of the patient ovulation. Methods Convenient selection ex-traction September 2014 to March 2016 our hospital 120 cases of polycystic ovary syndrome patients as research subjects, according to the digital table were randomly divided into three groups of 40 cases. One group received 2.5 mL of letrozole, set A group; a group with 5.0 mL of letrozole to group B; a group with 7.5 mL of letrozole to group C. Respectively, three groups of patients with different doses of the drug treatment and observe the patient's ovulation improvement after treatment. Results A group of patients with a total effective rate of 82.5%, 92.5% in group B, group C was 97.5%, A group and C group difference was statistically significant(P<0.05); A group of pregnancy and ovulation rate significantly lower than group C, the difference between groups was statistically significant(P<0.05). Conclusion Polycystic ovary syndrome patients higher doses of letrozole can effectively promote ovulation, increase the pregnancy rate, and secure, worthy of promotion.