初探血尿酸与高血压脑出血的相关性

目的：探讨外周血浆中尿酸与高血压脑出血的关系。方法整群选取2014年1月—2015年12月就诊于郑州市第六人民医院神经内科原发性高血压患者241例，以头颅CT影像学确诊有无脑出血，将患者分为脑出血组（147例）和高血压组（94例）。采用免疫法检测外周血中尿酸，以尿酸≥430 umol/L作为诊断高尿酸血症的标准。结果高血压性脑出血患者外周血中尿酸水平高于高血压组(503.4±40.2)比(447.3±38.8)，P<0.05。伴有高尿酸血症的高血压患者发生脑出血的比例高于高血压组患者（64.7%比9.6%，P<0.05）。多因素Logistic回归显示：影响高血压性脑出血的危险因素有高血脂（OR=1.08）、高尿酸血症（OR=1.04）、饮酒（OR=2.30）、收缩压（OR=1.10）、高同型半胱氨酸（OR=1.02）， P<0.01。结论高尿酸血症高血压患者更易发生脑出血，即高尿酸血症高血压患者发生脑出血的危险性更高。

A Preliminary Study the Correlation of Blood Uric Acid and Hypertension Cerebral Hemorrhage

Objective To investigate the relationship between cerebral hemorrhage in the peripheral blood plasma uric acid and hypertension. Methods Group selection into the group of 241 cases of patients with essential hypertension, to head CT imaging diagnosis for cerebral hemorrhage, divided the patients into cerebral hemorrhage group (147 cases) and hyperten-sion group (94 cases). By immune method in the detection of peripheral blood uric acid, uric acid 430 umol/L as the stan-dard of diagnosis of high uric acid hematic disease, hypertension patients with high uric acid hematic disease (156 cases), not in hypertensive patients with high uric acid hematic disease (85 cases). Results Peripheral blood uric acid level is higher than the high blood pressure in patients with hypertensive cerebral hemorrhage group (503.4 ±40.2) than (447.3 ± 38.8), P < 0.05. With high uric acid levels, a higher proportion of hypertensive cerebral hemorrhage in patients with high blood pressure patients (64.7%:9.6%, P< 0.05). Multiariable Logistic regression showed that the risk factors affecting hy-pertensive cerebral hemorrhage with hyperlipidemia (OR =1.08), high uric acid hematic disease (OR =1.04), alcohol (OR =2.30), systolic blood pressure(OR = 1.10), and homocysteine(OR = 1.02), P< 0.01. Conclusion Patients with high uric acid hematic disease high blood pressure are more likely to cerebral hemorrhage, namely high uric acid hematic disease risk of hypertension cerebral hemorrhage is higher.