降钙素原、C-反应蛋白在慢性阻塞性肺病合并细菌感染中的诊断价值

目的：探讨降钙素原、C-反应蛋白在慢性阻塞性肺病合并细菌感染中的诊断价值。方法随机选取该院2014年6月—2015年9月收治的慢性阻塞性肺病患120例,通过肺CT检查结果分为感染组60例,未感染组60例,另选取60名体检健康者作为正常对照组,分别测定其血清降钙素原(PCT)、C-反应蛋白(CRP)浓度,对感染组和未感染组患者使用抗菌药物一段时间后,再次测定PCT、CRP,并记录结果。结果感染组治疗前PCT为(2.49±2.87)μg/L、CRP浓度为(73.79±18.29)μg/L,与未感染组、正常对照组相比,差异有统计学意义(P﹤0.01)；治疗后感染组PCT为(1.98±0.11)μg/L、CRP浓度为(7.32±2.63)μg/L,较治疗前后差异有统计学意义(P﹤0.05),治疗前后,未感染组PCT、CRP浓度差异无统计学意义(P﹥0.05)；治疗后感染组PCT浓度为(1.98±0.11)μg/L,明显高于未感染组(P﹤0.05),CRP浓度与未感染组差异无统计学意义(P﹥0.05)。结论血清PCT联合CRP检测是诊断慢性阻塞性肺病患者是否合并细菌感染的较敏感的特异性指标,具有一定的临床指导意义。

Procalcitonin,C-reactive Protein in the Diagnosis Value of Chronic Ob-structive Pulmonary

Objective To investigate the procalcitonin, the diagnostic value of C- reactive protein in patients with COPD complicated with bacterial infection. Methods Random select our hospital from June 2014 to September 2015 treated 120 cases of chronic obstructive pulmonary disease (copd) with, through the lung CT examination results were divided into group of 60 cases of infection, uninfected group of 60 cases, the other selected as normal control group, 60 cases of physical health, respectively the serum calcitonin (PCT), C - reactive protein (CRP) concentration, the infected and uninfected group patients using antibacterial drugs after a period of time, determination of PCT and CRP, and record the results again . Re-sults PCT infection before treatment was (2.49 ± 2.87)μg/ L, CRP concentration was (73.79 ± 18.29)μg / L, compared with the uninfected group and normal control group were significantly different (P<0.01); after treatment for the infection PCT (1.98 ± 0.11)μg/L, CRP concentration was (7.32 ± 2.63)μg/L, compared before and after treatment difference was statistical-ly significant (P<0.05), after treatment, uninfected group PCT, CRP concentration was no significant difference(P>0.05 );af-ter treatment, the infected group PCT concentration was (1.98 ± 0.11)μg/L, significantly higher than the uninfected group, (P<0.05), CRP concentrations and uninfected group was no significant difference (P>0.05). Conclusion Serum PCT joint CRP in the diagnosis of chronic obstructive pulmonary disease patients whether to merge specific sensitive indicators of bacterial infection, has clinical significance.