鼻咽癌放疗后内分泌功能损伤的研究进展

鼻咽癌根治性放疗容易造成垂体-甲状腺的放射损伤，其损伤的程度与不同内分泌轴的固有敏感性、放疗剂量、年龄、时间等密切相关。放疗早期出现的内分泌损伤主要是亚临床的激素水平变化，而晚期损伤多为不可逆的腺体纤维化、功能减退等。调强放疗的应用能更好的保护内分泌腺体。

The Research Progress of Endocrine Dysfunction Induced by Radiotherapy for Nasopharyngeal Carcinoma Patients

The high radical doses assigned to nasopharyngeal carcinoma patients can easily induce endocrine dysfunction like pituitary and thyroid. The degree of damage is closely related to the inherent sensitivity of endocrine axis, the radiation doses, ages and survival time. In early phase after radiotherapy, subclinical changes of hormone levels were the main pre-sentation. The late stage injuries were irreversible fibrosis and hypofunction of glands. The application of intensity-modulat-ed radiotherapy can preserve the glands better.