肝功能检查对治疗肝硬化的临床作用

目的：探讨肝功能检查对肝硬化治疗的临床作用。方法随机选取2011年1月—2014年1月来该院治疗的肝硬化患者100例为研究对象，设为观察组，并以100例在该院体检正常的健康人为对照组。对两组进行肝功能检查，在检查前，避免食用辛辣、油腻食品，忌烟酒，于清晨空腹取3 mL静脉血，采用全自动生化分析仪检测血液中CHE (血清胆碱酯酶)、ALB(白蛋白)、CHO(血清胆固醇)及TBA(总胆汁酸)含量，并进行比较分析。结果观察组的CHE (血清胆碱酯酶)含量为(2311±855)U/L、ALB(白蛋白)含量为(31.4±6.7)g/L以及CHO(血清胆固醇)含量为(2.8±0.8) ummol/L均显著低于对照组，两者差异具有统计学意义(P<0.05)，观察组TBA(总胆汁酸)含量为(48.8±32.3)mol/L，显著高于对照组，两者差异有统计学意义(P<0.05)。治疗后，不同Child-Pugh分级患者的CHE、ALB、CHO水平均显著高于治疗前，两者差异有统计学意义(P<0.05)；不同Child-Pugh 分级患者的TAB水平均显著低于治疗前，两者差异有统计学意义(P<0.05)。结论CHE(血清胆碱酯酶)、ALB(白蛋白)、CHO(血清胆固醇)及TBA(总胆汁酸)水平等各项肝功能指标的检查对肝硬化患者的治疗及预后病情诊断具有重要意义。

Clinical Effect of Liver Function Test on The Treatment of Liver Cirrhosis

Objective To investigate the clinical effect of liver function examination in the treatment of liver cirrhosis. Methods Random selection 100 patients with liver cirrhosis treated in our hospital from January 2011 to January 2014 were selected as the research object, and were set as the observation group, and 100 cases in our hospital physical examination as normal control group. Liver function tests in the two groups. Before the test, to avoid eat spicy, greasy food, avoid alcohol. In the early morning fasting take 3 ml venous blood, using automatic biochemical analyzer was used to measure the blood cholinesterase (CHE), ALB (albumin), CHO (serum cholesterol and total bile acid (TBA), total bile acid content and compar-ative analysis. Results The contents of CHE (serum mol/L) were significantly lower in the observation group (2311 ±855) U/L, ALB (albumin) (31.4 ±6.7) g/L and CHO (2.8 ±0.8) ummol/L, the difference was statistically significant (P<0.05), and the content of TBA (total bile acid) was significantly higher than that in control group (P<0.05). After treatment, the levels of ALB, CHO and CHE were significantly higher than those before treatment, the difference was statistically significant (P<0.05). The TAB level of patients with different Child-Pugh levels were significantly lower than those before treatment, the difference was statistically significant (P<0.05). Conclusion CHE (serum ChE), ALB (albumin), CHO (serum cholesterol) and TBA (total bile acid) levels and other liver function indexes are important for the treatment and prognosis of patients with cirrhosis.