降钙素原在哮喘-慢阻肺重叠综合征应用性研究

目的：探讨降钙素原在哮喘-慢阻肺重叠综合征中的临床应用价值。方法整群选取2014年1月—2015年12月该院收治的52例ACOS急性加重患者作为ACOS组,选取同期治疗的86例单纯慢性阻塞性肺疾病患者作为对照组,分析比较两组患者血清PCT及CRP水平,并评价ACOS组PCT检测的敏感度及特异度。结果ACOS组患者血清PCT及CRP水平均高于对照组,差异有统计学意义(P<0.05)；PCT和CRP对ACOS急性加重患者细菌感染进行诊断, PCT诊断敏感度和特异度分别为95.65%、83.33%,均高于CRP诊断(83.33%、60.00%),PCT诊断阳性预测值、阴性预测值均高于CRP检测。结论PCT检查能够及时准确判断ACOS患者细菌感染情况,具有较好的灵敏度及特异度,为判断细菌感染的程度提供依据,有助于抗菌药物的合理应用,对于规范化治疗ACOS有明确的应用价值。

Procalcitonin Applied Research in Asthma-chronic Obstructive Pulmonary Disease Overlap Syndrome

Objective To investigate the clinical value of procalcitonin in ACOS. Mehods Group selection 52 cases of pa-tients from January 2014 to Derember 2015 with acute exacerbation ACOS as the observation group, select the same period of treatment 86 patients with chronic obstructive pulmonary disease alone as a control group, analyzed and compared two groups of patients with serum PCT and CRP levels and evaluate ACOS group PCT detection sensitivity and specificity de-gree. Results ACOS group with serum PCT and CRP levels were higher than the control group, a significant difference (P<0.05); PCT and CRP for the diagnosis of bacterial infection ACOS group, PCT diagnostic sensitivity and specificity were 95.65%, 83.33%, are higher CRP diagnosis (83.33%, 60.00%), PCT diagnostic positive predictive value、negative predictive value were higher than CRP. Conclusion CT inspection timely and accurately determine the bacterial infection in ACOS patients, with better sensitivity and specificity, to provide a basis for judging the degree of bacterial infection, help in the rational use of antimicrobial drugs for standardized treatment ACOS clear value.