尼莫地平治疗大面积脑栓塞的临床研究

目的 :从临床上观察尼莫地平注射液对脑栓塞治疗的有效性和安全性。方法 :选择诊断明确的急性脑栓塞病人 72例 ,随机分为尼莫地平治疗组和常规治疗对照组 ,在治疗前、后 14d分别对临床疗效及颅CT作比较。结果 :尼莫地平治疗组临床疗效评定总有效率为 73.7% ,显效率为 5 5 .3% ,明显优于常规治疗组 (41.2 %、14 .7% ) ,两组比较有显著差异 (P <0 .0 1,P <0 .0 0 5 ) ;复查颅CT发现治疗组的梗死灶明显缩小。结论 :临床观察尼莫地平注射液疗效满意 ,是治疗脑栓塞有效且安全的药物

Therapeutic Effect of Nimodipine on Acute Large Area Cerebral Embolism

Objective: To observe the clinical efficacy and safety of nimodipine infusion in the treatment of extensive cerebral embolism. Methods:54 cases of patient diagnosed with acute cerebral embolism were randomized into two groups: one receiving the therapy of nimodipine and another receiving routine therapy. The clinical condition and cerebral CT data before and after the treatment were compared between the two groups. Results:The total response rate and significant response rate in the nimodipine group were 73.7% and 55.3% respectively, that was absolutely better than those in the control group (41.2%and 14.7% respectively). There was statistically significant difference between the two groups ( P <0.01, P <0.005). The focus of infarction was found narrow by cerebral CT. Conclusion:Nimodipine infusion is effective and safe in treating patients with cerebral embolism.