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| 血清不对称性二甲基精氨酸浓度变化与慢性肾衰高血压相关性探讨 | |
| 引用本文： | 张卫茹,陶立坚,陈本美,熊燕,游运辉,陈立平. 血清不对称性二甲基精氨酸浓度变化与慢性肾衰高血压相关性探讨[J]. 中南大学学报(医学版), 2002, 27(2): 133-134 |
| 作者姓名： | 张卫茹 陶立坚 陈本美 熊燕 游运辉 陈立平 |
| 作者单位： | 1. 中南大学湘雅医院肾内科,长沙,410008 2. 中南大学湘雅医学院中心实验室,长沙,410008 3. 中南大学湘雅医学院药理教研室,长沙,410008 |
| 基金项目： | 湖南省自然科学基金资助 (OOJJY2 0 111) |
| 摘 要： | 采用高效液相色谱方法 (HPLC)检测 2 9例血液透析患者血、尿不对称性二甲基精氨酸 (asymmetricdimeth ylarginine ,ADMA)的浓度 ,并与血压作相关性分析。结果表明 :血液透析患者血清ADMA浓度明显升高 ,尿ADMA浓度降低 ,与正常对照组比较差异有显著性 (P <0 .0 1) ;血清ADMA浓度与收缩压及舒张压呈明显正相关 (分别为 r=0 .6 34,P <0 .0 1;r =0 .735 ,P <0 .0 1)。结果提示血液透析患者体内ADMA浓度增高 ,ADMA的蓄积可能参与了慢性肾衰高血压的病理生理过程 |
| 关 键 词： | 血液透析 不对称二甲基精氨酸 高血压 肾功能衰竭 |
| 文章编号： | 1000-5625(2002)02-0133-02 |
| 修稿时间： | 2001-08-10 |
Relationship between serum asymmetric dimethylarginine and blood pressure in patients with chronic renal failure |
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| ZHANG Wei ru,TAO Li jian,CHEN Ben mei,et al.. Relationship between serum asymmetric dimethylarginine and blood pressure in patients with chronic renal failure[J]. Journal of Central South University. Medical sciences, 2002, 27(2): 133-134 | |
| Authors: | ZHANG Wei ru TAO Li jian CHEN Ben mei et al. |
| Affiliation: | (Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China) |
| Abstract: | Objective To investigate the relationship between serum asymmetric dimethylarginine and blood pressure in patients with chronic renal failure. Methods We examined the levels of asymmetric dimethylarginine (ADMA) in the serum and urine of 29 hemodialysis patients using the HPLC method, and assessed the relationship between serum ADMA and blood pressure. Results The level of serum ADMA was higher, but the level of urinary ADMA was lower in the patients with chronic renal failure than those in the controls. The serum ADMA was positively related to blood pressure. Conclusion The accumulation of ADMA may be related to hypertension in patients with chronic renal failure. |
| Keywords: | hemodialysis asymmetric dimethylarginine hypertension renal failure |
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