曲伏前列腺素和卡巴胆碱对白内障超声乳化加人工晶状体植入术后24h眼压的影响

目的观察曲伏前列腺素和卡巴胆碱对白内障超声乳化加人工晶状体植入术后24 h眼压的影响。方法 2011年3月至2013年3月我科室行白内障超声乳化加人工晶状体植入术患者150例,150眼,随机分为A、B、C 3组。A组患者在手术前1 h于结膜囊内滴入曲伏前列腺素眼液1滴,B组患者术毕关闭切口前于前房内注射卡巴胆碱0.2 mL,C组患者术毕关闭切口前于前房注射卡巴胆碱0.2 mL,手术前于结膜囊内滴入曲伏前列腺素眼液1滴。测量并比较所有患者术前12 h及术后12、24 h眼内压力。结果与单用组(A、B组)相比,术后12 h,联合用药组(C组)眼压升高幅度最小,差异有统计学意义(P<0.05);术后24 h,联合用药组患者眼压下降幅度最大,差异有统计学意义(P<0.05)。结论曲伏前列腺素和卡巴胆碱联合用药在预防超声乳化人工晶体植入术后24 h内眼压升高起到了良好的协同作用,值得临床推广。

Effect of travoprost and carbachol on 24 h intraocular pressure after phacoemulsifi-cation and intraocular lens implantation

Objective To observe the clinical effect of travoprost and carbachol on intraocular pressure （ IOP） within 24 hours after cataract surgery. Methods 150 patients with high IOP resulted in phaco-emulsification with in-traocular lens （ IOL） implantation were randomly divided into group A （ instilling one drop of travoprost eyedrops into the culdesac about 1 h before the operation,group B （ intracameral carbachol） ,and group C （ travoprost with carbachol） . The intraocular pressure was measured 12 h before operation and 12,24 h after the surgery respectively. Results IOP were higher at 12 hours postoperatively than that of the preoperation,but group C was lower than group A and group B （P〈0. 05）. IOP at 24 hours after surgery decreased compared with 12 hours postoperatively and group C was the low-est （P〈0. 05）. Conclusion The preoperative treatment of travoprost and intraoperative treatment of carbachol togeth-er can significantly prevent high IOP within 24 hours after cataract surgery,it is worthy of chiical apphication.