| 黄芩自生酶催化水解总黄酮苷的工艺研究 |
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| 引用本文： | 刘志刚,颜仁梁,徐昌瑞,刘耀明. 黄芩自生酶催化水解总黄酮苷的工艺研究[J]. 解放军药学学报, 2008, 24(2): 130-132 |
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| 作者姓名： | 刘志刚 颜仁梁 徐昌瑞 刘耀明 |
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| 作者单位： | 广州军区广州总医院,广东,广州,510010;广东食品药品职业学院,广东,广州,510520;江西江中制药技术中心,江西,南昌,330077 |
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| 摘 要： | 目的研究黄芩自生酶催化水解总黄酮苷的工艺条件。方法采用正交试验，考察了加水量、温度和时间等因素，采用HPLC法测定了药材中黄芩苷、黄芩素、汉黄芩素、千层纸素-A的含量。结果确定最优酶催化水解工艺条件为取药材，加4倍量水，于32℃酶催化水解12h，烘干后备用。结论黄芩自生酶催化水解总黄酮苷是一种环保、经济、可行的方法。
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| 关 键 词： | 黄芩 总黄酮苷 自生酶 水解 黄芩素 汉黄芩素 千层纸素-A |
| 文章编号： | 1008-9926(2008)02-0130-03 |
| 修稿时间： | 2007-07-31 |
Study on Technology for Autogenesis-enzyme Hydrolysis Total Flavonoid Glycoside in Scutellaria |
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| LIU Zhi-Gang,YAN Ren-Liang,XU Chang-Rui,LIU Yao-Ming. Study on Technology for Autogenesis-enzyme Hydrolysis Total Flavonoid Glycoside in Scutellaria[J]. Pharmaceutical Journal of Chinese People's Liberation Army, 2008, 24(2): 130-132 |
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| Authors: | LIU Zhi-Gang YAN Ren-Liang XU Chang-Rui LIU Yao-Ming |
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| Affiliation: | LIU Zhi-Gang, YAN Ren-Liang, XU Chang-Rui, LIU Yao-Ming (Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong China;Guangdong Food and Drug Vocational College, Guangzhou 510520, Guangdong China;Jiangxi Jiangzhong Pharmaceutical Fctory Technology Center,Nanchang 330077 ,Jiangxi China) |
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| Abstract: | Aim To study optimial technology for autogenesis-enzyme hydrolysis of total flavonoid glycoside in scutellaria. Methods Using orthogonal experiments, water quantum,hydrolysis temperature and hydrolysis time were investigated. Concentrations of baicalin, baicalein, wogonin, oroxylin-A were analyzed by HPLC. Results The best hydrolysis technology was A3B3C3. The medical material should be hydrolyzed by 4 times（V） as much water at 32℃ and kept on for 12h before being dried by baking. Conclusion This is a pollution-free ,economic and feasible way to hydrolyze total flavonoid glycoside in scutellaria. |
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| Keywords: | Scutellaria Total flavonoid glycoside Autogenesis-enzyme Hydrolysis Baicalein Wogonin oroxylin-A |
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