| 阿仑膦酸钠治疗绝经后妇女骨质疏松症1年临床疗效观察 |
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| 引用本文： | 蔡飞龙.阿仑膦酸钠治疗绝经后妇女骨质疏松症1年临床疗效观察[J].海峡药学,2010,22(5):102-104. |
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| 作者姓名： | 蔡飞龙 |
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| 作者单位： | 浙江省绍兴县中心医院骨科,绍兴,312030 |
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| 摘 要： | 目的观察阿仑膦酸钠对绝经后妇女骨质疏松症的治疗作用。方法口服阿仑膦酸钠,70 mg每周1次,连用1年,分别在6个月和12个月观察骨密度、U-Ca、U-Cr和U-Ca/U-Cr。结果治疗后6个月和12个月,腰椎L2-4、股骨颈、大转子和全髋骨密度较治疗前都有显著提高（P〈0.05）,治疗12个月后与治疗6个月后比较差异也有统计学意义（P〈0.05）;治疗6个月后和治疗12个月后U-Ca和U-Ca/U-Cr较治疗前都有显著降低（P〈0.05）,且治疗12个月后U-Ca和U-Ca/U-Cr与治疗6个月后比较差异也有统计学意义（P〈0.05）;而U-Cr治疗前后差异则无统计学意义（P〉0.05）。结论阿仑膦酸钠对绝经后妇女骨质疏松症有很好的治疗作用。
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| 关 键 词： | 阿仑膦酸钠 绝经 骨质疏松症 骨密度 空腹尿钙 尿肌酐 |
The efficacy of 1 year alendronate therapy in postmenopausal women with osteoporosis |
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| CAI Fei-long.The efficacy of 1 year alendronate therapy in postmenopausal women with osteoporosis[J].Strait Pharmaceutical Journal,2010,22(5):102-104. |
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| Authors: | CAI Fei-long |
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| Institution: | CAI Fei-long(Zhejiang province shaoxing center Hospital orthopaedist shaoxing 312030,China) |
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| Abstract: | OBJECTIVE To observe the effect of alendronate on osteoporosis of postmenop-ausal women.METHODS The women chosen were given 70 mg per week alendmnate for 1 year,and then observed the BMD,U-Ca,U-Cr and U-Ca/U-Cr.RESULTS 1 year alenclrormte therapy produced a significant increase in BMD at the lumbar spine,femoral neck,trochanter and total hip（P〈0.05）,and it was the same 6 months after treatment.The values of U-Ca and U-Ca/U-Cr at the basehne,6 months,and 12 months after taking alendronate were statistical significance（P〈0.05）,but the U-Cr were statistically simitar（P〉0.05）.CONCLUSION Alendronate was effective and safe in postmenopausal women with ostooporosis. |
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| Keywords: | Alendronate Postmenopausal Osteoporosis BMD U-Ca U-Cr |
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