黄芪预防术后硬膜外粘连的实验研究

目的：探讨黄芪预防术后硬膜外瘢痕粘连的效果。方法：22只新西兰兔行L2和L5节段2椎板切除术，切除部分黄韧带，暴露脂肪，去除硬膜外脂肪，分为两组：A组为黄芪组；B组为生理盐水组，分别在L2和L5椎板缺损区注入黄芪液和生理盐水，术后2、4、8周取材作光镜，透镜观察。结果：黄芪组炎性细胞渗出较少，成纤维细胞较少，胶原纤维形成较少，硬膜外瘢痕无粘连，脊髓和神经根未见变性和脱髓鞘，生理盐水组硬膜外明显。结论：黄芪无神经毒性作用，可作为作一种良好的材料用于预防术后硬膜外瘢痕粘连。

An experimental study of prevent ive effects of Huangqi on postoperative peridural adhesion

Objective;To study the effects of Huangqi(Chinese herb)for prevention of peridural adhesio n after operation. Methods;L₂ and L₅ laminectomy of 22 New Zealan d rabbits were performed in this experim ental study.Partial yellow ligament was sectioned and fat was exposed.Then the p eridural fat was sectioned.The 44 verteb ral lamina seyments were randomly divide d into two groups of a. Huangqi group an d b.Normal Saline(NS)group.The b group wa s control group.Huangqi liquid and NS we re separately injected into the defect p oints of L₂ and L₅ vertebral lamina of the two groups.The speciments were obta ined at 2nd,4th and 8th weeks after oper ation.Optical microscope and transmissio n electron microscope were used for the observation. Results;There were many changes in group a;littl e migration of inflammation cells,small number of fibroblast and collagen,no adh esion of peridural scar,no degeneration and demyelination of spinal nerves.But i n group b,adhesion of peridural scar cou ld be seen clearly. Conclusion;Huangqi has no nerve toxicity and it cou ld be used as a good medicine to prevent postoperative peridural adhesion.