口服特比奈芬治疗甲真菌病临床随机试验的Meta分析

目的 用Meta分析的方法对国内外已发表的高质量的有关比较特比奈芬的疗效和安全性的临床随机双盲对照试验进行综合定量分析，为甲真菌病治疗中抗真菌药物的选择提供参考依据。方法 收集国内外已公开发表的有关特比奈芬与安慰剂、伊曲康唑、灰黄霉素比较的治疗甲真菌病的临床随机双盲对照试验，对符合要求的研究进行Meta分析。结果 入选的特比奈芬与安慰剂比较的研究有3项，特比奈芬与伊曲康唑比较的研究有3项．在临床试验结束阶段的真菌镜检和真菌培养转阴率方面，特比奈芬明显高于对照组和伊曲康唑组，并且具有统计学意义，而且认为特比奈芬在耐受性方面优于伊曲康唑；特比奈芬与灰黄霉素比较的临床试验有2项，特比奈芬的真菌治愈率明显高于灰黄霉素。结论 特比奈芬在治疗甲真菌病方面具有明显优势。

Terbinafine in Fungal Infections of the Nails:a Meta-analysis of Randomized Double-blind Clinical Trials

Objectives To carry out a meta-analysis to evaluate the efficacy and safety of Terbinafine in comparison with placebo, Itraconazole and Griseofulvin. Methods The analysis used data from published trials, supplemented where necessary by reference to the original trial reports. Results Three trials were included in which Terbinafine was compared with placebo. From three trials comparing Terbinafine with Itraconazole, a statistically significant advantage in favour of Terbinafine was observed for negative culture and microscopy at the end of the trials. From two trials comparing Terbinafine with Griseofulvin, a significantly higher rate of negative microscopy and culture was observed with Terbinafine. Conclusions A significant advantage in favour of treatment with Terbinafine was observed.