Doppler Echocardiographic Predictors of Mortality in Female Rats After Myocardial Infarction |
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| Authors: | Alexandra Alberta Santos Izzo Helber Ronald LG Flumignan Ednei L Antonio Antonio C Carvalho Ângelo A Paola Paulo J Tucci Valdir A Moises |
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| Institution: | 1. Department of Vascular Medicine, University Medical Center Utrecht, The Netherlands;2. Department of Radiology, University Medical Center Utrecht, The Netherlands;3. Department of Neurology, University Medical Center Utrecht, The Netherlands;4. Department of Vascular Surgery, University Medical Centre Utrecht, The Netherlands;5. Department of Cardiology, University Medical Center Utrecht, The Netherlands;6. Department of Cardiology, Dupuytren University Hospital, Limoges, France;1. Department of Physical Education, Exercise Biology Laboratory, Universidade Federal de Viçosa (UFV), Viçosa, Minas Gerais, Brazil;2. Departament of General Biology, Structural Biology Laboratory, Universidade Federal de Viçosa (UFV), Viçosa, Minas Gerais, Brazil;3. School of Physical Education and Sport, Biochemistry and Molecular Biology Laboratory, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil;4. Department of Veterinary Medicine, Universidade Federal de Viçosa (UFV), Viçosa, Minas Gerais, Brazil;5. Veterinary Medicine, Universidade Vila Velha (UVV), Vila Velha, Espírito Santo, Brazil;1. Department of Cardiovascular Medicine, Shinshu University, Matsumoto, Japan;2. Department of Anatomy and Organ Technology, Shinshu University, Matsumoto, Japan;3. Department of Biotechnology and Biomedical Engineering, Institute for Biomedical Sciences, Shinshu University, Matsumoto, Japan;4. Molecular Pharmacology, Shinshu University, Matsumoto, Japan;5. Department of Molecular and Cellular Pharmacology, Iwate Medical University, Iwate, Japan;6. Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan;1. Dept of Physiological Sciences, Federal University of Espirito Santo, Brazil;2. Dept of Medicine, Federal University of Sao Paulo, Brazil;3. Dept of Structural and Functional Biology, State University of Campinas, Brazil;4. Heart Institute, University of Sao Paulo, Brazil;5. Institute of Biomedical Sciences, University of Sao Paulo, Brazil |
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| Abstract: | BackgroundDoppler echocardiogram is useful for the evaluation of anatomical and functional changes in late myocardial infarction (MI) in rats. However, no studies have evaluated the prognostic value of echocardiographic parameters 1 week after MI.Methods and ResultsDoppler echocardiogram was performed in 84 female Wistar rats 1 week after MI to determine infarction size, left chambers dimensions, fractional area change (FAC) of the left ventricle (LV), mitral inflow and tissue Doppler, myocardial performance index (MPI), and signs of pulmonary hypertension. The 365-day follow-up showed 53.6% mortality rate. Nonsurvivors showed larger (P < .05) MI size and cavity dimensions, poorer diastolic and systolic function, and higher frequency of pulmonary hypertension. Parameters at early stage of MI associated with higher mortality risk by Cox multivariate regression model were FAC ≤37% (relative risk RR] 3.78, 95% CI, 1.50–9.53), MPI ≥0.60 (RR 3.49, 95% CI, 1.80–6.76), LV systolic area ≥0.26 cm2 (RR 4.38, 95% CI, 1.88–10.21), E/E' ratio ≥20.3 (RR 2.12, 95% CI, 1.15–4.34), and E/A ratio associated with FAC (RR 2.99, 95% CI, 1.44–6.18).ConclusionSome diastolic and systolic Doppler echocardiographic parameters in rats may be able to predict late mortality risk after MI. |
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