鼻炎宁颗粒辅助治疗变应性鼻炎的临床观察

目的:观察鼻炎宁颗粒用于治疗中重度持续性变应性鼻炎的疗效、对生活质量影响及其安全性。方法:入选的中重度持续性变应性鼻炎患者177例,按就诊的先后次序随机分为A组、B组和C组。A组治疗采用布地奈德鼻喷雾剂喷鼻。B组为布地奈德鼻喷雾剂喷鼻,同时冲服鼻炎宁颗粒。C组为布地奈德鼻喷雾剂喷鼻,同时口服盐酸西替利嗪片。治疗结束后对3组疗效、治疗前后生活质量改善情况及不良反应进行分析比较。结果:治疗1周后A、B、C组有效率分别为47%、67%、74%,A组有效率分别与B、C组比较,差异有统计学意义(P<0.05),B组有效率与C组比较差异无统计学意义(P>0.05)。治疗2周后A组、B组、C组有效率分别为60%、79%、82%,A组有效率分别与B、C组比较,差异有统计学意义(P<0.05),B组有效率与C组比较差异无统计学意义(P>0.05)。3组患者治疗前后总体生活质量评分差异均有统计学意义(P<0.05);治疗后总体生活质量评分比较,A组与B、C组差异有统计学意义(P<0.05),B组与C组差异无统计学意义(P>0.05)。所有患者治疗过程中均未出现严重不良事件。A、B、C组不良反应发生率分别为13.3%、15.3%、22.4%,未见鼻炎宁颗粒相关不良反应发生。结论:鼻炎宁颗粒治疗中重度持续性变应性鼻炎有一定的疗效,与布地奈德鼻喷剂联合应用时其作用与盐酸西替利嗪片相当,且不良反应少。

Clinical trial of Biyanning Granule as Complementary Treatment of Allergic Rhinitis

Objective:To evaluate the efficacy and safety of Biyanning Granule on moderate to severe persistent allergic rhinitis.Methods:To compare efficacy,quality of life,safety of Biyanning and Cetirizine hydrochloride tablet on top of Budesonide nasal spray in 177 patients.Group A was treated with Budesonide nasal spray,group B with Budesonide plus Biyanning Granule,group C with Budesonide plus Cetirizine hydrochloride tablet.Results:After one week,the effective rates of group A,B and C was 47%,67% and 74%,and there was significant difference between group A and B or A and C(P < 0.05),but not significant between group B and C(P >0.05).After two weeks,the effective rates of group A,B and C was 60%,79% and 82%,there was significant difference between group A and B or A and C(P < 0.05),but not significant between group B and C(P > 0.05).There was significant improvement of quality of life after treatment for all groups(P < 0.05).Quality of life of Group A was significantly better than that of group B or C,but not significant between group B and C.Without severe adverse reaction,the AE occurence rates were 13.3 %,15.3 % and 22.4 %.Conclusion:Biyanning Granule has corrective efficacy for moderate to severe persistent allergic rhinitis.The combined effect with Budesonide nasal spray is as good as Cetirizine Hydrochloride with less adverse drug reactions.