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| 加味四逆散对睡眠剥夺大鼠PFC和海马CA3区NMDA受体表达的调节作用 | |
| 引用本文： | 范新六,李峰,宋月晗,洪志强,马佳美,刘燕.加味四逆散对睡眠剥夺大鼠PFC和海马CA3区NMDA受体表达的调节作用[J].世界中医药,2012,7(3):261-262. |
| 作者姓名： | 范新六 李峰 宋月晗 洪志强 马佳美 刘燕 |
| 作者单位： | 1. 世界中医药学会联合会北京御方堂中医门诊部,北京市朝阳区小营路19号,100101;世界中医药学会联合会 2. 北京中医药大学 3. 世界中医药学会联合会 |
| 摘 要： | 目的:研究睡眠剥夺大鼠PFC和海马CA3区NMDAR2B和NMDAR2B(Tyr1472)表达的变化,并观察加味四逆散对其影响。方法:采用多平台法,进行连续睡眠剥夺168h,使用Westernblot技术分析大鼠PFC和海马CA3区NMDAR2B和NMDAR2B(Tyr1472)表达的变化。结果:与对照组比较,模型组大鼠PFC和海马CA3区NMDA受体NMDAR2B和NMDAR2B(Tyr1472)蛋白质的表达明显减少(P<0.05)。与模型组比较,加味四逆散组大鼠PFC和海马CA3区NMDAR2B和NMDAR2B(Tyr1472)蛋白质的表达均明显增加(P<0.05)。结论:加味四逆散能上调睡眠剥夺导致PFC区NMDAR2B、NMDAR2B(Tyr1472)表达的降低;也能上调睡眠剥夺导致海马CA3区NMDAR2B表达的降低。 |
| 关 键 词： | 睡眠剥夺 加味四逆散 NMDA受体 |
| 收稿时间： | 2012/2/28 0:00:00 |
Regulation of Jiawei Sini Powder on Expression of PFC and CA3 NMDA Recepters |
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| Fan Xinliu,Li Feng,Song Yuehan,et al..Regulation of Jiawei Sini Powder on Expression of PFC and CA3 NMDA Recepters[J].World Chinese Medicine,2012,7(3):261-262. | |
| Authors: | Fan Xinliu Li Feng Song Yuehan |
| Institution: | Fan Xinliu1,3,Li Feng2,Song Yuehan2,et al.(1.Yu Fang Tang TCM Clinics of WFCMS,Add.:No.19,Xiaoying Road,Chaoyang District,Beijing,Post code:100101;2.Beijing University of Chinese Medicine;3.WFCMS) |
| Abstract: | Objective:To investigate expression of PFC,NMDAR 2B and NMDAR 2B(Tyr1472) in rats deprived of sleep,and the impact of Jiawei Sini Powder.Methods:Using multi-platform to deprive rats of sleep for consecutively 168h,and using Western blot to analyze changes of expression of PFC,NMDAR 2B and NMDAR 2B(Tyr1472).Results:Compared with control group,the model group decreased significantly in above mentioned expressions(P < 0.05).Compared with the model group,the rats taken Jiawei Sini Powder had the expressions increased significantly(P < 0.05).Conclusion:Jiawei Sini Powder can raise the decreased expressions of PFC,NMDAR 2B and NMDAR 2B(Tyr1472) in rats caused by sleep deprivation. |
| Keywords: | Sleep deprivation Jiawei Sini Powder NMDA recepter |
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