乙酰甲胺磷·三唑磷乳油的毒性研究

目的研究以乙酰甲胺磷和三唑磷为主要成分的乳油的急性毒性，为其毒理安全性评价提供依据。方法按国家标准GB15670—1995进行急性经口、经皮、吸入毒性试验，急性皮肤及眼刺激试验、皮肤致敏试验。结果20％乙酰甲胺磷·三唑磷乳油对雌雄性sD大鼠经口LD50均为369mg／kg．BW；急性经皮LD50〉2000mg／kg．BW；急性吸入LC50〉2000mg／m3；对家兔皮肤刺激反应积分均值为0；急性眼刺激积分指数（I．A．O．I．）=6．0，（M．I．0．I．）48h为0；对豚鼠皮肤致敏率为0。结论20％乙酰甲胺磷·三唑磷乳油经口毒性属于中等毒，经皮毒性属于低毒，吸入毒性属于低毒，时眼睛有轻度刺激性。对皮肤无刺激性，对豚鼠致敏强度分类为弱致敏。

Study on acute toxicity of 20% acephate-triazophos emulsifiable concentrate

Objective To investigate the acute toxicity of 20% acephate-triazophos emulsifiable concentrate （EC）and provide evidence for assessment of toxicological security. Methods According to ＂Toxicological test methods of pesticides for registration＂ （GB15670-1995）. acute oral toxicity test, acute dermal toxicity test, acute inhaling toxicity test, acute dermal and eye irritation test and skin sensitisation test were carried out on rats and rabbits respectively. Results The oral LD50 of 20% acephate-triazophos EC was 369mg/kg.BW,the dermal LD50 was〉2 000mg/kg.BW and the inhalation LC50 was〉 2000mg/m3. The mean index of skin irritation on rabbits was 0. The highest index of eye irritation on rabbits was 6 and the mean index of eye irritation （2 days later） was 0.The rate of skin sensitization on guinea pigs was 0. Conclusion The oral toxicity of 20% acephate-triazophos EC was graded as moderate, the dermal and inhalation toxicity were low,the eye irritation was low , the skin irritation was none, and the skin sensitization was feeble.