冠心病炎症因子表达及其与冠状动脉病变危险分数的相关性

目的探讨炎症在动脉粥样硬化发展中的作用和临床意义及其与冠状动脉病变危险分数的相关性。方法选择急性冠脉综合征患者56例，包括急性心肌梗死（AMI）组26例，不稳定心绞痛（UAP）组30例，以同期住院的冠状动脉造影检查正常的30例患者作为对照（C）组，进行对比研究。采用酶联免疫吸附法测定血清sICAM-1和hs-CRP水平，并对UAP患者冠脉病变的结果进行危险评分。结果血清sICAM-1浓度AMI组明显高于UAP组和对照组，而UAP组明显高于对照组；血清hs CRP浓度AMI组明显高于UAP组和对照组，但UAP组与对照组比较无显著差异。UAP患者血清sICAM-1浓度与冠状动脉危险分数相关（r=0．445，P〈0．05），而hs CRP浓度与冠状动脉危险分数无明显相关性。结论炎症参与了急性冠脉综合征的发生发展过程，血清sICAM-1浓度与冠状动脉危险分数相关，可作为冠心病病情监测的指标之一。

Expression of inflammatory factors in coronary atherosclerosis and the relationship between the factors and coronary risk score

Objective To investingate the role of inflammation in coronary atherosclerosis and the relationship between the inflammatory factors and coronary risk score. Methods 56 patients with acute coronary syndrome were studied, among them 26 cases were diagnosed as acute myocardial infarction (AMI) and 30 unstable angina pectoris (UAP). The study group was compared with a control group of 30 cases who were identified as normal by coronary angiography. The concentrations of serum sICAM-1 and hsCRP were determined by ELISA assay. The coronary risk score was recorded in patients with UAP. Results Serum sICAM-1 levels were significantly elevated in patients with AMI or UAP compared with that of control group, while higher hsCRP level was observed only in the patients with AMI compared with those with UAP and the control group. By linear regression analysis, only serum sICAM-1 levels were correlated with coronary risk score (r=0.445, P<0.05) in UAP patients. Conclusions Inflammation participates in the initiation and development of ACS. As inflammatory factors, serum sICAM-1 level is correlated with coronary risk score, and it can be used as an index in monitoring the condition of patients with coronary disease.