Potentiation of Enteral Absorption of Human Interferon Alpha and Selective Transfer into Lymphatics in Rats |
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| Authors: | Yoshikawa Hiroshi Takada Kanji Satoh Yu-ichiro Naruse Norio Muranishi Shozo |
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| Institution: | (1) Department of Biopharmaceutics, Kyoto Pharmaceutical University, Kyoto, Japan;(2) Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607, Japan;(3) Basic Research Laboratories, Toray Industries, Inc., Kamakura, Japan |
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| Abstract: | Enhancement of human leucocyte interferon (HuIFN- ) absorption from rat large intestine was studied with the aid of lipid, surfactant and lipid-surfactant mixed micelles. Neither the emulsified lipid (linoleic acid) nor the surfactant (HCO60, polyoxyethylated 60 moles] hydrogenated castor oil) alone were able to enhance the absorption of HuIFN-. However, linoleic acid-HCO60 mixed micelles enhanced the absorption of HuIFN- from the large intestine. Highly selective delivery of HuIFN- into the lymphatics compared to the blood was also observed. |
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