FOLFOX4方案治疗晚期胃癌40例临床观察

目的观察FOLFOX4方案治疗晚期胃癌的临床疗效及毒副反应。方法40例晚期胃癌患者，给予FOLFOX4方案化疗。即：奥沙利铂（L-OHP）85mg／m^2。静脉点滴，2h，dl；亚叶酸钙（LV）200mg／m^2，静脉点滴，2h，d1，d2；氟尿嘧啶（5-FU）400mg／m^2静脉推注，后600mg／m^2微泵持续静脉滴注22h，d1，d2；每2周重复，4周为1周期。均治疗2周期以上，按WHO标准评价客观疗效和毒副反应。结果全组40例均可评价疗效，其中完全缓解（CR）3例，部分缓解（PR）17例，稳定（SD）13例，进展（PD）7例，总有效率（CR＋PR）50．0％。中位肿瘤进展时间（m）5．7个月，中位生存时间（MST）为9．8个月。毒副反应主要是骨髓抑制，胃肠道反应及外周神经毒性。白细胞下降发生率为75．0％。主要为Ⅰ／Ⅱ度反应，恶心呕吐发生率62．5％，腹泻30．0％。口腔粘膜炎22．5％。L—OHP引起的可逆性周围神经毒性发生率为45．0％，表现为肢端感觉异常，遇冷加重，但患者一般都能耐受。结论FOLFOX4方案治疗国人晚期胃癌的近期疗效较好，毒副反应可以耐受，值得进一步研究应用。

Clinical study on oxaliplatin combined with 5-fluorouracil and leucovorin in the treatment of advanced gastric cancer

Objective To evaluate the efficacy and toxicity of oxaliplatin combined with 5-fiuorouraeil and leucovorin in the treatment of advanced gastric cancer. Methods Forty patients with advanced gastric cancer were treated with chemotherapy of regimen ： oxaliplatin 85 mg/m^2 d, ivgtt, dl ; LV 200 mg,/m^2 ivgtt 2 h followed by 5 -Fu 400 mg/m^2 （bolus） and 5 -Fu 600 mg/m^2 （ 22h-eoutinous infusion） d1,2 and repeated every 2 weeks ,4 weeks for one cycle. All patients received two cycles of chemotherapy at least. Efficacy was evaluated after 4 cycles. Results 3 patients achieved complete remission （CR）, 17 patients partial remission （PR）, 13 patients stable disease（SD） ,7 patients progression disease（ PD ）. Overall response rate was 50.0%. The median time to progression （mTFP） was 5.7 months. The median survival time （MST） was 9.8 months. The major toxicity included leueopenia,nausea,vomiting and neurosensory abnormity. Conclusion It was concluded that the regimen of FOLFOX4 is effective and tolerable in advanced gastric cancer.