用药效指标筛选小半夏加茯苓颗粒剂的工艺

采用硫酸铜灌胃作呕吐动物模型，以呕吐潜伏期和呕吐次数为测评指标，运用正交试验法，采用四因素三水平进行提取工艺的选优，并在此基础上制备成小半夏加茯苓颗粒剂。优选的提取工艺为Ａ２Ｂ３Ｃ２，即药材粉碎成粗粉，第一次加９倍量水，煎煮４５ｍｉｎ，第二次加５倍量水，煎煮３０ｍｉｎ，滤液浓缩成浸膏，按浸膏：糊精：蔗糖粉＝１：３：０．５的比例制备成小半夏加茯苓颗粒剂。

Applying Pharmaceutical Effect Indexes to Screen out the Preparation Technology of Xiaobanxia Added Fuling Granules

After having adopted vomiting animal model created by filling stomach with cuprum sulfuricum and after having selected incubation period and vomiting index as our measuring and commenting indexes. We prepared decoction of Xiaobanxia added Fuling granules by applying orthogonal experimental method with four factors and three levels to proceed a preferable choice of extracting technology.The superior extracting technology became A2B3C2, namely: comminuting medicinal materials into coarse powder, for the first time, adding 9 times dosage of water and decocting for 45 minutes, for the second time, adding 5 times dosage of water and decocting for 30 minutes, condensing the filtrate to light paste ( specific gravity 1.25 - 1.27, assaying at 25 centigrade) ,preparing decoction of Xiaobanxia added Fuling granules with a proportion as below: light paste: amylin: saccharose powder = 1:3:0.5.