| Increased serum and ascitic fluid levels of soluble tumor necrosis factor-p55 in hepatocellular carcinoma patients |
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| 引用本文： | 高蕾,白岚,南清振,杨希山,陈凯,温汉平,柏林,张亚历,张振书. Increased serum and ascitic fluid levels of soluble tumor necrosis factor-p55 in hepatocellular carcinoma patients[J]. 中国人民解放军军医大学学报, 2002, 17(3) |
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| 作者姓名： | 高蕾 白岚 南清振 杨希山 陈凯 温汉平 柏林 张亚历 张振书 |
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| 作者单位： | Department of Oncology，157 Hospital of Chinese PLA，Guangzhou 510510，China，Institute of Digestive Diseases of Chinese PLA，Nanfang Hospital，First Military Medical University，Guangzhou 510515，China，Institute of Digestive Diseases of Chinese PLA，Nanfang Hospital，First Military Medical University，Guangzhou 510515，China，Institute of Digestive Diseases of Chinese PLA，Nanfang Hospital，First Military Medical University，Guangzhou 510515，China，Department of Oncology，157 Hospital of Chinese PLA，Guangzhou 510510，China，Department of Oncology，157 Hospital of Chinese PLA，Guangzhou 510510，China，Institute of Digestive Diseases of Chinese PLA，Nanfang Hospital，First Military Medical University，Guangzhou 510515，China，Institute of Digestive Diseases of Chinese PLA，Nanfang Hospital，First Military Medical University，Guangzhou 510515，China，Institute of Digestive Diseases of Chinese PLA，Nanfang Hospital，First Military Medical University，Guangzhou 510515，China |
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| 摘 要： | Objective: To explore the levels of serum and ascitic fluid soluble tumor necrosis factor receptor-p55 (sTNFR-p55) and understand their clinical implication in primary hepatocellular carcinoma (HCC) patients. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to examine the levels of sTNFR-p55 in the serum and ascitic fluid in 25 HCC patients and 25 patients with liver cirrhosis (LC). The test was also performed on the serum of 30 healthy subjects who served as control group. To assess the clinical effects of increased serum concentrations of sTNFR-p55, four parameters were analyzed by logistic regression. Results: Serum and ascitic fluid levels of sTNFR-p55 in HCC patients were significantly higher than those in LC patients and controls (P=0. 001). No significant difference was found between serum sTNFR-p55 levels in the latter 2 groups (P = 0. 19), and positive correlation between serum levels of sTNFR-p55 and that in ascitic fluid was noted in the 2 patient groups (r=1. 000, P<0. 001). Level
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Increased serum and ascitic fluid levels of soluble tumor necrosis factor-p55 in hepatocellular carcinoma patients |
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| GAO Lei,BAI Lan,NAN Qing-zhen,YANG Xi-shan,CHEN Kai,WEN Han-ping,BO Lin,ZHANG Ya-li,ZHANG Zhen-Shu. Increased serum and ascitic fluid levels of soluble tumor necrosis factor-p55 in hepatocellular carcinoma patients[J]. Journal of Medical Colleges of PLA(China), 2002, 17(3) |
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| Authors: | GAO Lei BAI Lan NAN Qing-zhen YANG Xi-shan CHEN Kai WEN Han-ping BO Lin ZHANG Ya-li ZHANG Zhen-Shu |
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| Abstract: | Objective: To explore the levels of serum and ascitic fluid soluble tumor necrosis factor receptor-p55 (sTNFR-p55) and understand their clinical implication in primary hepatocellular carcinoma (HCC) patients. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to examine the levels of sTNFR-p55 in the serum and ascitic fluid in 25 HCC patients and 25 patients with liver cirrhosis (LC). The test was also performed on the serum of 30 healthy subjects who served as control group. To assess the clinical effects of increased serum concentrations of sTNFR-p55, four parameters were analyzed by logistic regression. Results: Serum and ascitic fluid levels of sTNFR-p55 in HCC patients were significantly higher than those in LC patients and controls (P=0. 001). No significant difference was found between serum sTNFR-p55 levels in the latter 2 groups (P = 0. 19), and positive correlation between serum levels of sTNFR-p55 and that in ascitic fluid was noted in the 2 patient groups (r=1. 000, P<0. 001). Levels of the sTNFR-p55 positively correlated with TBIL and AFP in the peripheral blood of HCC patients (r=0. 524, P = 0. 01 and r=0. 234, P = 0. 03, respectively). Conclusion: Increased levels of sTNFRs-p55 in the serum and ascitic fluid could reflect the abnormal immune status of the HCC patients and may help predict the development of the tumor. |
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| Keywords: | hepatocellular carcinoma soluble tumor necrosis factor receptors enzyme-linked immunosor- bent assay |
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