子宫内膜异位症术后达菲林与达那唑辅助治疗的临床观察

目的探讨子宫内膜异位症患者术后达菲林、达那唑辅助治疗的临床效果。方法 36例行腹腔镜治疗并经病理证实的子宫内膜异位症患者随机分为达菲林组与达那唑组,各18例。达菲林组给予达菲林3.75 mg,第1天,第28天,第56天,第84天,皮下注射,12周为1个疗程。达那唑组给予达那唑200 mg/次,2次/d,口服,月经第1天开始连续服用,12周为一个疗程。2组患者均在治疗1个疗程后4周随访。观察两组治疗的临床疗效、治疗前后VRS评分情况、术后妊娠情况及治疗后药物毒副反应。结果达菲林组的临床缓解率、改善率均高于达那唑组,复发率低于达那唑组。治疗后两组VRS评分均较治疗前明显降低(P<0.01);达菲林组治疗后VRS评分明显低于达那唑组治疗后(P<0.01)。达菲林组妊娠率为66.7%;达那唑组妊娠率为45.5%。2组不良反应发生情况无显著差异。结论达菲林能显著缓解子宫内膜异位症患者痛经症状,复发率低,适于临床广泛使用。

Clinical observation of dipherelin and danazol assisted therapy for postoperative endometriosis

Objective To explore the clinical efficacy of dipherelin and danazol assisted therapy for postoperative endometriosis patients.Methods A total of 36 patients who received laparoscopic treatment and had pathologically-confirmed endometriosis were randomly divided into dipherelin group(n=18) and danazol group(n=18).Dipherelin group was administered dipherelin 3.75 mg,subcutaneous injection at day 1,day 28,day 56,day 84,12 weeks as a treatment cycle.Danazol group was administered danazol 200 mg/time,twice a day,oral intake at day 1 of menstruation,12 weeks as a treatment cycle.The two groups were followed up four weeks after a treatment cycle.The clinical efficacy,VRS scores before and after treatment,postoperative pregnancy and adverse events of the two groups were observed.Results The clinical remission rate and improvement rate were higher in the dipherelin group than in danazol group,but the recurrence rate was lower in the dipherelin group than in the danazol group.After treatment,the VRS scores were significantly lower(P<0.01) in both groups.But the VRS score was significantly lower in dipherelin group than in the danazol group(P<0.01).The pregnancy rate was 66.7% in the dipherelin group and 45.5% in the danazol group.No significant differences between the two groups were found in the incidence of adverse reactions.Conclusion Dipherelin can significantly relieve dysmenorrhea symptoms of endometriosis patients with low recurrence rate and it is worthy of wider clinical application.