药品不良反应的统计分析与临床合理用药的探讨

目的了解本院药品不良反应(ADR)发生的特点及规律,提高ADR监测工作质量,促进临床合理用药。方法对本院2009年10月~2011年9月上报的143例ADR,分别从患者的年龄、性别、给药途径、药品种类、抗感染药物类别,涉及器官或系统以及具体临床表现等方面进行回顾性分析。结果 143例ADR中,女性(90例)多于男性(53例);由抗感染药物引起的ADR数量居首位,有121例(84.62%);给药途径以静脉滴注为主,有134例(83.2%);临床表现以皮肤及附件损害最为常见。结论应进一步加强本院ADR的监测和宣传工作,提高专业人员责任意识,减少ADR的发生,以保证药物在临床中安全有效的使用。

Statistical analysis of adverse drug reactions and exploration of rational clinical drug use

Objective To explore the characteristics and patters of adverse drug reaction(ADR) in our hospital,improve the quality of ADR monitoring,and promote rational clinical drug use.Methods Data of 143 patients with ADR from October 2009 to September 2011 in our hospital were retrospectively analyzed in terms of age,sex,route of administration,drug types,category of anti-infection drugs,organs and systems involved and clinical manifestations.Results The females(90 cases) was more than the males(53 cases).The number of ADR(121 cases,84.62%) created by anti-infection drugs ranked the first.The route of administration was primarily intravenous drip infusion(134 cases,83.2%).The clinical manifestations were most common in skin and accessory damage.Conclusion We need to enhance the monitoring and publicizing of ADR and improve the responsibility consciousness of the professional staff in order to reduce the incidence of ADR and guarantee the safe and effective use of drugs in clinical treatment.