Terbinafine-induced hepatic failure requiring liver transplantation. |
| |
Authors: | Zeeshan Perveze Mark W Johnson Raymond A Rubin Marty Sellers Carlos Zayas Jody L Jones Rosemary Cross Kimberly Thomas Bradley Butler Roshan Shrestha |
| |
Affiliation: | Piedmont Transplant Services, Piedmont Hospital, Atlanta, GA 30342, USA. |
| |
Abstract: | Drug-induced liver disease accounts for about 50% of acute or subacute liver failure in the United States. United Network of Organ Sharing (UNOS) data suggest 8%-20% of liver transplantation in this country per year is for fulminant liver failure due to drugs. Even though the most common medication implicated in acute liver injury is acetaminophen (75%), there are numerous other drugs that are responsible for acute and chronic liver injury. A variety of antifungal medications are known to cause a wide range of liver injury from a mild hepatocellular-cholestatic injury pattern to acute/subacute liver failure. Terbinafine is one of the antifungals that have been associated with such liver injuries. We report a case of terbinafine-induced severe liver failure requiring liver transplantation. |
| |
Keywords: | |
|
|