四种血脂脂蛋白比值对冠心病诊断价值的比较

目的比较总胆固醇/高密度脂蛋白胆固醇(TC/HDL-C)、甘油三酯/HDL-C(TG/HDL-C)、低密度脂蛋白胆固醇/HDL-C(LDL-C/HDL-C)、载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)四项比值对冠心病(CHD)的诊断价值。方法分析453例CHD患者和98例正常对照组的TC、TG、HDL-C、LDL-C、ApoB、ApoA1水平,计算TC/HDL-C、TG/HDL-C、LDL-C/HDL-C、ApoB/ApoA1比值,进行分析比较。结果CHD组TC/HDL-C、TG/HDL-C、LDL-C/HDL-C、ApoB/ApoA1比值分别为4．88±1．66、1．78±1．76、3．16±1．24、0．87±0．32,显著高于正常对照组的3．85±0．99、0．90±0．49、2．32±0．77、0．75±0．19(t=5．932、4．930、6．403、3．477,P＜0．001)。CHD组四项比值的异常率分别为42．6%、46．3%、47．2%、34．2%,明显高于正常对照组的14．3%、17．3%、11．2%、18．4%(x~2=27．549、27．991、43．258、9．396,P＜0．01)。LDL-C/HDL-C比值的异常率及OR值高于其它血脂指标。结论TC/HDL-C、TG/HDL-C、LDL-C/HDL-C、ApoB/ApoA1比值对CHD的诊断价值均大于各单项血脂指标,而LDL-C/HDL-C和TG/HDL-C比值水平与CHD的相关更强。

Comparison of diagnostic values of four kind of serum lipids lipoprotein ratio for coronary heart disease

Objective To compare the diagnostic value of total cholesterol/high density lipoprotein cholesterol (TC/HDL-C),triglycerin/high density lipoprotein-cholesterol (TG/HDL-C),low density lipoprotein cholesterol/highdensity lipopro-teincholesterol (LDL-C/HDL-C)and apolipoproteinB/ apolipoproteinA1 (ApoB/ApoA1) ratio for coronary heart disease (CHD).Methods TC,TG,HDL-C,LDL-C, ApoB,ApoA1 levels of 453 patients with CHD group and 98 normal control group was analysed.TC/ HDL-C,TG/HDL-C,LDL-C/HDL-C,ApoB/ApoA1 ratio were counted,analysed and compared.Results TC/ HDL-C,TG/HDL-C,LDL-C/HDL-C,ApoB/ApoA1 ratio of group with CHD (4.88±1.66,1.78±1.76,3.16±1.24,0.87±0.32) was higher obviously than those of normal control group (3.85±0.99,0.90±0.49,2.32±0.77,0.75±0.19),and difference between them was significant (t=5.932,4.930,6.403,3.477,P＜0.001). Abnormal rate of four kind of ratio of group with CHD(42.6%,46.3%,47.2%,34.2%) was higher obviously than those of normal control group (14.3%,17.3%,11.2%,18.4%),and difference between them was significant (X~2=27.549,27.991,43.258,9.396,P＜0.01).Abnormal rate and OR value of LDL-C/HDL-C ratio was higher than the other serum lipids lipoprotein index.Conclusion The diagnostic value of TC/HDL- C,TG/HDL-C,LDL-C/HDL-C,ApoB/ApoA1 ratio for CHD is higher than monomial serum lipids lipoprotein index.LDL-C/HDL-C and TG/HDL-C ratio is more correlative with CHD.