FR109615, a new antifungal antibiotic from Streptomyces setonii. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity |
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| Authors: | T Iwamoto E Tsujii M Ezaki A Fujie S Hashimoto M Okuhara M Kohsaka H Imanaka K Kawabata Y Inamoto |
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| Affiliation: | Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan. |
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| Abstract: | FR109615, a new antibiotic active against Candida, was isolated from Streptomyces setonii No. 7562. Based on the spectroscopic data, the structure of FR109615 was elucidated as cis-2-aminocyclopentane-1-carboxylic acid (1). The compound showed the excellent in vivo efficacy in a generalized infection test of mice. |
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