溃疡性结肠炎合并肠道菌群失调的临床研究

目的研究抗生素的应用对溃疡性结肠炎(ulcerative colitis,UC)患者肠道菌群的影响。方法 60例UC患者按照近1个月内是否应用抗生素分为抗生素组(40例)和非抗生素组(20例),入院后第2天按照《全国临床检验操作规程》行大便肠道菌群检测。结果抗生素组正常菌群5例,I度菌群失调8例,Ⅱ度菌群失调17例,Ⅲ度菌群失调10例;非抗生素组大便检验为正常菌群13例,Ⅰ度菌群失调4例,Ⅱ度菌群失调3例,Ⅲ度菌群失调0例。抗生素组UC患者肠道菌群失调发生率较非抗生素组明显增加,差异有统计学意义(P0.05)。结论抗生素应用使UC患者发生肠道菌群失调的风险增加。

Clinical research of ulcerative colitis combind with gut microflora imbalance

Objective To investigate the effect of antibiotic on the intestinal microbiota of patients with ulcerative colitis （UC）.Methods Sixty UC patients were divided into antibiotic group and non-antibiotic group according to the application of antibiotics or not during last month.Fecal coccus-bacillus ratio test was conducted referring to the National Guide to Clinical Laboratory Procedures two days after admission.Results The fecal coccus-bacillus ratio in the antibiotic group,5 cases were normal,8 cases were Ⅰ degree dysbacteriosis,17 cases were Ⅱ degree dysbacteriosis,10 cases were Ⅲ degree dysbacteriosis.The fecal coccus-bacillus ratio in the non-antibiotic group,13 cases were normal,4 cases were Ⅰ degree dysbacteriosis,3 cases were Ⅱ degree dysbacteriosis,there was no Ⅲ degree dysbacteriosis.In the antibiotic group of UC patients,the incidence rate of the disorder in intestinal flora obviously increased than that of the nonantibiotic group （P ＜ 0.05）.Conclusion The application of antibiotics has a significant effect on the intestinal microbiota of patients with UC.