1,6二磷酸果糖对急性心肌缺血大鼠心功能及内啡肽的影响

结扎大鼠左冠状动脉前降支.造成心肌急性缺血后.引起血液、垂体、部分脑区和心肌组织中β—内啡肽含量的显著上升.并伴有心功能的抑制.急性心肌缺血大鼠给于1.6二磷酸果糖后.可减少β—内啡肽含量的增高.改善心功能.提示1.6二磷酸果糖改善心功能的作用.可能不仅通过改善能量代谢.心肌缺血、缺氧的直接作用.而且还可能通过减少β—内啡肽的过度释放.从而减弱对心功能的抑制.间接地改善心功能.

The effect of fructose-1,6-diphosphate on cardiac function and endorphin in acute myocardial ischemia in rats

In this study, acute cardiac ischemia was induced by ligation of the anterior descending branch of the coronary artery in rats. Radioimmunoassay was conducted to measure the contents of immunoreactive beta - en-dorphin (ir-β-EP)after ischemia and fructose -1,6 - diphosphate (FDP) treatment. Results showed that the contents of ir-β-EP were in-cereased in the plasma, some brain areas, pituitary and myocardium after ligation of the left coronary artery of the rats which resulted in the deterioration of the cardiac function includingdp/dtmax, Lvsp, total areas of force loop and blood pressure. Intravenous administration of FDP improved cardiac function and reduced the contents of ir - β - EP in the above mentioned tissues suggesting that ir-β-EP correlate closely with cardiac function after ischemia,the reduction of which was possibly involved in the improve ment of cardiac function by FDP.