An integral approach to the measurement of glomerular filtration rate |
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| Authors: | Alfred S. Malowany Richard R. Mildenberger John D. Harries K. N. Drummond |
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| Affiliation: | (1) Department of Electrical Engineering, McGill University, PO Box 6070, 101 Montreal, Qu., Canada;(2) Department of Anesthesia, McMaster University, Hamilton, Canada;(3) Montreal Children's Hospital Research Institute, Montreal, Canada |
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| Abstract: | The paper presents a method for the accurate clinical measurement of kidney glomerular filtration rate using a single injection of tracer and the collection of plasma and urine samples. The method is based on an integral-equation approach and is implemented by computerised curve fitting of the plasma-concentration data. The urine-collection procedures are simplified, and errors are reduced. Plasma-only methods are shown to be special cases of the general integral equation, and their limitations are stated. |
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| Keywords: | Glomerulus filtration |
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