| 线粒体三磷酸腺苷敏感性钾通道与心肌预适应 |
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| 引用本文： | 钟标,钟焕清,陈海生. 线粒体三磷酸腺苷敏感性钾通道与心肌预适应[J]. 医学综述, 2006, 12(2): 100-101 |
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| 作者姓名： | 钟标 钟焕清 陈海生 |
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| 作者单位： | 广东省高州市人民医院心外科,广东,高州,525200 |
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| 摘 要： | 近年来大量的研究提示,应用钾通道开放剂(PCOs)与缺血预适应(IPC)同样具有明显的抗心肌缺血再灌注损伤的作用,而线粒体三磷酸腺苷敏感性钾通道(mitoKATP)在其中起着重要的作用,其机制尚未明了,可能与以下三方面有关:减少线粒体Ca2+超载,调节线粒体容量与能量代谢,调节自由基的生成。
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| 关 键 词： | 缺血再灌注损伤 线粒体 ATP敏感性钾通道 心肌保护 预适应 |
| 文章编号： | 1006-2084（2006）02-0100-02 |
| 收稿时间： | 2005-07-06 |
| 修稿时间： | 2005-12-10 |
Mitochondrial ATP-Sensitive K+ Channels and Myocardial Preconditioning |
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| ZHONG Biao,ZHONG Huan-qing,CHEN Hai-sheng. Mitochondrial ATP-Sensitive K+ Channels and Myocardial Preconditioning[J]. Medical Recapitulate, 2006, 12(2): 100-101 |
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| Authors: | ZHONG Biao ZHONG Huan-qing CHEN Hai-sheng |
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| Abstract: | Recently,many researches indicated that potassium channel openers(PCOs)protect the heart against ischemia-reperfusion injury as remarkably as ischemic preconditioning(IPC)does.And mitochondrial ATP-sensitive K+ channel(mitoKATP)plays an important role in the protection.The protective mechanism of mitoKATP is unclear,However,it has a close relation to decreasing in mitochondrial Ca 2+ uptake,regulating the releases of reactive oxygen species,regulating mitochondrial volume and energetic metabolism are believed to be involved. |
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| Keywords: | Ischemia-reperfusion injury Mitochondria ATP-sensitive potassium channels Cardioprotection Preconditioning |
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