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雷帕霉素抑制IgA肾病大鼠肾小球信号蛋白STAT3的活化
引用本文:戎赞华,段惠军,郝军,王晨,史永红.雷帕霉素抑制IgA肾病大鼠肾小球信号蛋白STAT3的活化[J].基础医学与临床,2008,28(5):460-464.
作者姓名:戎赞华  段惠军  郝军  王晨  史永红
作者单位:河北医科大学,病理学教研室,河北,石家庄,050017;河北医科大学,病理学教研室,河北,石家庄,050017;河北医科大学,病理学教研室,河北,石家庄,050017;河北医科大学,病理学教研室,河北,石家庄,050017;河北医科大学,病理学教研室,河北,石家庄,050017
摘    要:目的探讨雷帕霉素对IgA肾病大鼠肾组织p-JAK2、STAT3、p-STAT3和PCNA表达的影响。方法制备IgA肾病动物模型,分为对照组、IgA肾病组、氯沙坦(ls)和雷帕霉素(rapa)治疗组。监测大鼠的生化指标及用免疫组化、Western blot、RT-PCR等方法检测肾组织p-JAK2、STAT3、p-STAT3和PCNA的蛋白及mRNA的表达。结果IgA肾病大鼠较对照组24 h尿蛋白定量明显升高、血白蛋白降低、BUN以及Cr水平明显升高(P<0.01);IgA肾病大鼠p-JAK2、STAT3、p-STAT3和PCNA蛋白及mRNA水平也显著高于对照组;雷帕霉素能显著缓解上述改变(P<0.01)。结论雷帕霉素可能通过抑制IgA肾病大鼠肾小球JAK/STAT信号途径、直接抑制STAT3的活化以及抑制系膜细胞的增殖而减轻病变程度。

关 键 词:雷帕霉素  IgA肾病大鼠  p-JAK2  STAT3  p-STAT3
收稿时间:2008-1-30
修稿时间:2008-3-10

Rapamycin inhibits activation of STAT3 in renal tissue of IgA nephropathy rats
RONG Zan-hua,DUAN Hui-jun,HAO Jun,WANG Chen,SHI Yong-hong.Rapamycin inhibits activation of STAT3 in renal tissue of IgA nephropathy rats[J].Basic Medical Sciences and Clinics,2008,28(5):460-464.
Authors:RONG Zan-hua  DUAN Hui-jun  HAO Jun  WANG Chen  SHI Yong-hong
Abstract:Objective To investigate the effects of rapamycin on p-JAK2,STAT3,p-STAT3 and PCNA in ranal tissue of IgAN rats.Methods The animal models of IgA nephropathy were devided into control group,IgAN model group,losartan group and rapamycin group.The clinical efficacy of rapamycin,and its influences on the protein and mRNA expressions of STAT3,p-STAT3,p-JAK2 and PCNA were determined by western blot,RT-PCR and immunohistochemical techniques respectively.Results The protein and mRNA expressions of p-STAT3,STAT3,p-JAK2 and PCNA were significantly increased in kidney of IgAN rats(P<0.01);Rapamycin down-regulated these excessive expressions(P<0.01).Conclusion Rapamycin may extenuate the pathological damage of IgAN rats by inhibiting JAK/STAT signaling pathway,activation of STAT3 and mesangial proliferation.
Keywords:rapamycin  IgA nephropathy rat  p-JAK2  STAT3  p-STAT3
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