脊髓步行中枢模式发生器

一般认为，哺乳动物（包括人在内）都是通过脊髓步行中枢模式发生器（CPG）控制步行运动，而CPG网络的边界是灵活的，脊髓损伤后脊髓步行CPG可实现网络重组。研究显示，减重步行平板训练（BWSTT）可使脊髓横断猫完全恢复后肢步行能力；临床也发现，脊髓损伤患者可通过BWSTT提高步行能力，表明脊髓可能具有运动学习的能力。因此，如何利用脊髓步行CPG的神经可塑性，为脊髓损伤患者制定最佳的步行训练方案，是令人关注的问题。

Spinal Locomotor Pattern Generator (review)

It is generally accepted that locomotion in mammals, including humans, is based on the activity of neuronal circuits within the spinal cord (the central pattern generator, CPG). Recent studies indicate a plastic behavior of the spinal neuronal circuits following a spinal cord injuries (SCI). Studies have shown that body weight support treadmill training (BWSTT) is effective in restoring locomotor function in cats with a complete spinal lesion. It has become possible to regain some locomotor activity in patients with spinal cord injury through an intense training on BWSTT, as in cat. So, it is a staired problem how to take advantage of the plasticity of spinal locomotor pattern generator and design the gait training program for SCI patients.