| 肝内胆管癌细胞9810凋亡和bcl-2基因表达关系研究 |
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| 引用本文： | 夏光涛,张尚忠,史朝晖. 肝内胆管癌细胞9810凋亡和bcl-2基因表达关系研究[J]. 临床肝胆病杂志, 2004, 20(3): 170-171 |
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| 作者姓名： | 夏光涛 张尚忠 史朝晖 |
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| 作者单位： | 山东大学齐鲁医院消化科,山东,济南,250012;山东大学齐鲁医院消化科,山东,济南,250012;山东大学齐鲁医院消化科,山东,济南,250012 |
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| 摘 要： | 应用阿霉素诱导肝内胆管癌细胞 9810凋亡 ,研究其凋亡与bcl- 2基因表达之间的关系。应用流式细胞仪检测肝内胆管癌细胞凋亡的情况 ,并同时检测bcl- 2基因表达。随着阿霉素浓度的增加 ,细胞凋亡率逐步上升 ,同时bcl- 2基因表达下调。bcl- 2基因表达下调是阿霉素诱导肝内胆管癌细胞凋亡机制之一。
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| 关 键 词： | 肝内胆管癌 阿霉素 凋亡 bcl-2基因 |
| 文章编号： | 1001-5256(2004)03-0170-02 |
| 修稿时间： | 2003-09-12 |
Study of the relation between the apoptosis of intrahepatic cholangiocarcinoma cell lines 9810 and expression of bcl-2 gene |
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| XIA Guang-tao, ZHANG Shang-zhong, SHI Zhao-hui. Study of the relation between the apoptosis of intrahepatic cholangiocarcinoma cell lines 9810 and expression of bcl-2 gene[J]. Chinese Journal of Clinical Hepatology, 2004, 20(3): 170-171 |
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| Authors: | XIA Guang-tao ZHANG Shang-zhong SHI Zhao-hui |
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| Abstract: | To investigate the relation between apoptosis of intrahepatic cholangiocarcinoma cell lines 9810 and expression of bcl-2 gene. We detect its apoptosis and expression of bcl-2 gene by flow cytometer. Apoptosis of intrahepatic cholangiocarcinoma was up step by step flowing Adriacin's concentration, expression of bcl-2 gene was down as well as it. Influencing expression of bcl-2 gene may be a reason of apoptosis of intrahepatic cholangiocarcinoma cell. |
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| Keywords: | intrahepatic cholangiocarcinoma Adriacin apoptosis bcl-2 gene |
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