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| 脂肪细胞型脂肪酸结合蛋白与代谢综合征相关 | |
| 引用本文： | 李秋桂,蒋建华,张宝,马秦,肖永康.脂肪细胞型脂肪酸结合蛋白与代谢综合征相关[J].中华内分泌代谢杂志,2009,25(3). |
| 作者姓名： | 李秋桂 蒋建华 张宝 马秦 肖永康 |
| 作者单位： | 1. 安徽厌科大学公共卫生学院,合肥,230032 2. 安徽医科大学第一附属医院营养部 3. 安徽省疾病预防控制中心 |
| 基金项目： | 安徽省自然科学基金，安徽省教育厅自然科学研究项目 |
| 摘 要： | 代谢综合征(MS)组(n=121)的血清脂肪细胞型脂肪酸结合蛋白(A-FABP)水平较对照组(n=120)显著升高(14.7±4.8 vs 6.8±3.0)μg/L,P<0.001].腹型肥胖MS患者的血清A-FABP水平较非腹型肥胖MS患者显著升高(15.7±4.2 vs 12.6±5.1)μg/L,P<0.001].血清A-FABP水平与体重指数、腰围、腰臀比、空腹胰岛素、稳态模型评估的胰岛素抵抗指数、空腹血糖、甘油三酯、总胆同醇及平均动脉压等指标均呈正相关(r分别为0.603、0.534、0.411、0.424、0.401、0.370、0.460、0.208和0.522,均P<0.05),而与HDL-C旱显著负相关(r=-0.448,P<0.001). |
| 关 键 词： | 脂肪细胞型脂肪酸结合蛋白 肥胖症 代谢综合征 |
Relationship between adipocyte fatty acid-binding protein and metabolic syndrome |
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| LI Qiu-gui,JIANG Jian-hua,ZHANG Bao,MA Tai,XIAO Yong-kang.Relationship between adipocyte fatty acid-binding protein and metabolic syndrome[J].Chinese Journal of Endocrinology and Metabolism,2009,25(3). | |
| Authors: | LI Qiu-gui JIANG Jian-hua ZHANG Bao MA Tai XIAO Yong-kang |
| Abstract: | Serum adipocyte fatty acid-binding protein (A-FABP) was raised in metabolic syndrome (MS)patients (n= 121) as compared with age-matched healthy subjects n = 120, (14.7±4.8 vs 6.8 ±3. 0) μg/L,P<0.001]. It reached higher level in MS subjects with visceral obesity (15.7±4.2 vs 12.6±5.1) μg/L, P<0.001]. Serum A-FABP concentration was positively correlated with body mass index, waist circumference, waist-tohip ratio, fasting insulin, homeostasis assessment for insulin resistance (HOMA-IR), fasting glucose, triglycerides,total cholesterol,and mean arterial blood pressure, whereas negatively correlated with HDL-C (r =-0. 448, P< 0.001). |
| Keywords: | Adipocyte fatty acid-binding protein Obesity Metabolic syndrome |
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