组织工程骨血管化策略的研究进展

骨组织工程的发展为大段骨缺损的修复提供了新的途径,众多的动物实验研究和逐渐兴起的临床应用研究已充分显示出其巨大的应用前景。然而,组织工程骨细胞支架复合物在植入体内后,尤其植入血供不佳的受区时,因不能及时地与机体建立起血供连接,使得成骨效果不稳定。近年来的研究表明,组织工程骨的血管化已成为构建大段组织工程骨的一个关键因素。我们对组织工程骨血管化策略的研究进展进行综述。

Vascularization Strategy of Tissue Engineered Bone

The development of bone tissue engineering provides a promising way to repair large segment of bone defects. And it has already showed tremendous potential for application on the basis of numerous animal experiments and rising clinic studies. However, osteogenesis of the tissue engineered bone （TEB） grafts may be unstable after TEB constructs implanted in vivo, especially in sites with poor blood supply. Recent studies have demonstrated that the vascularization of TEB plays a vital role in generating large segment of bone grafts. In this article, the advances of TEB vascularization strategy were reviewed.