| 大鼠局灶性脑缺血再灌注后ICAM-1表达及甲基强的松龙干预实验研究 |
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| 引用本文： | 鞠鹏初,于维东,鞠诣然. 大鼠局灶性脑缺血再灌注后ICAM-1表达及甲基强的松龙干预实验研究[J]. 中国组织工程研究与临床康复, 2000, 4(6) |
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| 作者姓名： | 鞠鹏初 于维东 鞠诣然 |
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| 作者单位： | 辽宁省人民医院!辽宁沈阳110015(鞠鹏初,居乃新),中国医科大学第一临床学院(于维东),锦州石化医院(鞠诣然),辽宁省金秋医院(郝久宽) |
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| 摘 要： | 目的:探讨细胞间粘附分子 -1(ICAM -1)在脑缺血再灌注损伤中的作用及甲基强的松龙(MP)干预后的影响。方法 :采用栓线法制备大鼠大脑中动脉(MCA)缺血再灌模型 ,运用免疫组化方法检测ICAM -1的表达 ,并观察脑组织病理学改变。结果 :ICAM -1明确表达于脑缺血再灌组手术侧半球的微血管内皮 ,MP干预后阳性微血管数减少 ,多形核白细胞浸润减少 ,组织损伤程度相对较轻。结论 :局灶性脑缺血再灌注可诱导局部脑微血管内皮细胞ICAM -1的表达 ,其表达与脑组织坏死关系密切。MP可减少ICAM -1的表达及多形核白细胞浸润。
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| 关 键 词： | 脑缺血再灌注损伤 细胞间粘附分子-1 甲基强的松龙 |
Experimental study of ICAM-1 expression after focal cerebral ischemia and reperfusion in the rat and the interference effect of methylprednisopone |
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| JU Pengchu,YU Weidong,JU Yiran,et al.. Experimental study of ICAM-1 expression after focal cerebral ischemia and reperfusion in the rat and the interference effect of methylprednisopone[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2000, 4(6) |
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| Authors: | JU Pengchu YU Weidong JU Yiran et al. |
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| Affiliation: | JU Pengchu,YU Weidong,JU Yiran,et al.The People's Hospital of Liaoning Province,Sheng yang 110015,China |
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| Abstract: | Objective:To study the function of ICAM-1 in cerebral ischemiareperfusion injury and the influences by methylprednisolone(MP).Methods:MCA(Middle Cerebral Artery)occlusion was induced by advansing a nylon filament into the internal carotid artery.ICAM-1 expression was detected by immunohistochemical method,and histopathological changes were studied.Results:ICAM-1 expression was clearly identified on microvessels in the ipsilateral hemisphere of the MCAocclusion animals.The numbers of ICAM-1-positive microvessels and infiltrating leukocytes were decreased in MPtreated animals,and tissue injury was relatively reduced. Conclusion :Focal cerebral ischemia reperfusion enhances ICAM-1 expression on brain microvessels.MP reduced ICAM-1 expression and leukocyte infiltration in ischemic tissue. |
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| Keywords: | cerebral ischemiareperfusion injury ICAM-1 methylprednisolone |
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