| 我国登革2型病毒包膜E蛋白B区抗原表位的预测 |
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| 引用本文： | 康高飞,雷鸣.我国登革2型病毒包膜E蛋白B区抗原表位的预测[J].海南医学,2009,20(6). |
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| 作者姓名： | 康高飞 雷鸣 |
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| 作者单位： | 1. 湖南省新化县人民医院检验科,湖南新化,417600
2. 广东省东莞市虎门中医院,广东,东莞,523000 |
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| 摘 要： | 目的 预测登革2型病毒包膜E蛋白B区抗原表位.方法 采用哈佛大学分子免疫基金会在线提供的抗原肽预测软件结合Hopp & woods亲水性参数、Janin可及性参数、极性参数、柔韧性参数及二级结构方案对登革2型病毒包膜E蛋白B区抗原表位进行预测.结果 登革2型病毒包膜E蛋白B区抗原表位可能位于第40-46位、第121-147位,第131-137位氨基酸区域内或附近,这2个被预测的区域均含有β-转角或无规卷曲结构.结论 该研究对应用合成肽抗原进行登革热早期诊断及相关抗体的制备具有重要指导意义.
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| 关 键 词： | 登革病毒 E蛋白B区 抗原表位 |
Prediction of B cell epitope in B domain of envelope E protein of Chinese dengue 2 virus |
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| KANG Gao-fei,Lei Ming.Prediction of B cell epitope in B domain of envelope E protein of Chinese dengue 2 virus[J].Hainan Medical Journal,2009,20(6). |
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| Authors: | KANG Gao-fei Lei Ming |
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| Institution: | KANG Gao-fei,Lei Ming. Laboratory Departmnent,People's Hospital of Xinhua County,Xihua 417600,Hunan,P. R. CHINA |
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| Abstract: | Objective To predict B cell epitope in B domain of envelope E protein of Chinese dengue 2 virus. Methods Various algorithms and internet were used,including of antigenic peptide prediction from MIF sever,Hopp & woods hydrophility,accessibility (Janin),polarity flexibility and protein secondary structure prediction from SOPMA sever. Results It showed that B cell epitopes in envelope E protein of Chinese dengue 2 virus probably located in or were adjacent to amino acids 40-46,121-147,131-137. All the 3 predic... |
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| Keywords: | Dengue virus B domain of envelope E protein Epitope |
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