A Two-Generation Reproduction Study in Rats Receiving Drinking Water Containing Vinyl Acetate |
| |
Authors: | MEBUS, C. A. CARPANINI, F. M. B. RICKARD, R. W. CASCIERI, T. C. TYLER, T. R. VINEGAR, M. B. |
| |
Affiliation: | *DuPont Haskell Laboratory for Toxicology and Industrial Medicine Newark, Delaware 19714 BP International Limited England TW16 7LN Hoechsi Celanese Corporation Somerville, New Jersey 08876 Union Carbide Chemicals and Plastics Company, Inc. Danbury, Connecticut 06817 Quantum Chemical Corporation Cincinnati, Ohio 45249 Received August 13, 1993; accepted August 4, 1994 |
| |
Abstract: | Vinyl acetate (VA) is a commonly used chemical in polymerizationand copolymerization processes and as a chemical intermediate.As part of a collaborative effort between VA producers of theUnited States and British Petroleum, the present study was carriedout to provide a base set of data for risk assessment. Groupsof male and female Crl:CD(SD)BR rats were given 0, 200, 1000,or 5000 ppm VA via the drinking water over two generations.In addition, a cross-mating trial of control and 5000-ppm maleand female rats was conducted in the F1 generation to investigatethe slightly decreased litter production in the high-dose group.No treatment-related mortality was observed in any of the groups.Water consumption was significantly reduced in the 5000-ppmgroups in both generations and in the 1000-ppm F1, female rats.The body weights of the F0 and F1 male rats and the F1, femalerats in the 5000-ppm group tended to be slightly lower thanthose of the control group. Body weight gain was significantlydecreased during lactation in the F0 females at 5000 ppm andin the F1, females at 1000 and 5000 ppm. Pup weights in theF1, generation, but not in the F2 generation, were significantlylower than those of the control on lactation Day 21. The numberof litters produced in the F1 generation in the 5000-ppm groupwas slightly lower than that of the control group and was attributedto lower fertility. Fewer pups were produced when control femaleswere mated with the 5000-ppm males; however, the decrease wasdue to poor mating performance rather than decreased fertility.No decrease was apparent when the 5000-ppm females were matedwith the control group males. Under the conditions of this study,the no-observed adverse effort level was considered to be 1000ppm. |
| |
Keywords: | |
本文献已被 Oxford 等数据库收录! |
|