| 核苷类抗病毒前药的研究进展 |
| |
| 引用本文： | 冷玲颖,CAI Zhi-qiang,孙铁民. 核苷类抗病毒前药的研究进展[J]. 中国药物化学杂志, 2008, 18(4): 310-316 |
| |
| 作者姓名： | 冷玲颖 CAI Zhi-qiang 孙铁民 |
| |
| 作者单位： | 沈阳药科大学,制药工程学院,辽宁,沈阳,110016 |
| |
| 摘 要： | 一些核苷类抗病毒药物口服给药后，水溶性和口服生物利用度都很差，对这些药物进行修饰，制成其前药的形式，来克服这些不足是非常重要的。该文阐述了近年来核苷类抗病毒前药的设计方法，列举了一些核苷类抗病毒前药并讨论了这些化合物的活性机理。
|
| 关 键 词： | 核苷类抗病毒前药 伐昔洛韦 法昔洛韦 缬更昔洛韦 |
| 收稿时间： | 2007-09-03 |
| 修稿时间： | 2008-05-20 |
Strategy in the study of nucleoside antiviral prodrugs |
| |
| LENG Ling-ying,CAI Zhi-qiang,SUN Tie-min. Strategy in the study of nucleoside antiviral prodrugs[J]. Chinese Journal of Medicinal Chemistry, 2008, 18(4): 310-316 |
| |
| Authors: | LENG Ling-ying CAI Zhi-qiang SUN Tie-min |
| |
| Affiliation: | (School of Pharmaceutical Engineering, Shengyang Pharmaceutical University,Shangyang 110016, China) |
| |
| Abstract: | Abstract: Some of the nucleoside antiviral drugs suffer from low aqueous solubility and low bioavailability following oral administration. New nucleoside analogues, which were developed to overcome this problem, are very important. In this review, we intend to highlight the designing ways of antiviral nucleoside prodrugs which were developed in recent years wich examples. And their action mechanisms are discussed. |
| |
| Keywords: | nucleoside antiviral prodrugs valaciclovir famciclovir valganciclovir |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国药物化学杂志》浏览原始摘要信息 |
|
