Adrenal Function in Asthmatic Children Treated with Inhaled Budesonide |
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Authors: | H BISGAARD S PEDERSEN M DAMKJÆR NIELSEN O ØSTERBALLE |
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Institution: | From the Department of Paediatrics, University Hospital of Copenhagen, County of Gentofte, Copenhagen, Denmark;Department of Paediatrics, County Hospital of Kolding, Denmark;Department of Clinical Physiology, University Hospital of Copenhagen, County of Glostrup, Copenhagen, Denmark;Department of Paediatrics, County Hospital of Viborg, Denmark |
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Abstract: | Bisgaard, H., Pedersen S., Damkjær Nielsen M and Østerballe O. (Department of Paediatrics, University Hospital of Copenhagen, County of Gentofte, Copenhagen; Department of Paediatrics, County Hospital of Kolding; Department of Clinical Physiology, University Hospital of Copenhagen, County of Glostrup, Copenhagen; Department of Paediatrics, County Hospital of Viborg, Denmark). Adrenal function in asthmatic children treated with inhaled budesonide. Acta Paediatr Scand 80: 213, 1991 The effect of the inhaled topical steroid budesonide on adrenal function was evaluated in 33 children (aged 7–15 years) with moderate bronchial asthma. The trial was designed as a prospective single-blind study of the effect of budesonide in daily doses of 200 μg through 400 μg to 800 μg in three randomized consecutive periods of 8 weeks. The unstimulated diurnal production of cortisol was assessed by measurement of free cortisol in 24-hour urine samples at the end of each period. No significant dose-related suppression was found. The cortisol production did not differ significantly during treatment with 800 μg budesonide as compared to treatment with 200 μg budesonide (95% confidence interval: 74%–112%). It is concluded, that budesonide is a topical steroid with a favourable ratio between topical and systemic effects in asthmatic children. |
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Keywords: | budesonide adrenal function systemic activity bronchial asthma children |
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