急性心梗患者血清超敏C-反应蛋白与心梗指标的相关性分析

目的　探讨隐匿型冠心病患者及急性心肌梗死 (AMI)患者血清超敏CRP(hs -CRP)与其他心梗指标 ,包括磷酸肌酸激酶 (CK) ,磷酸肌酸激酶同工酶 (CK -MB) ,肌钙蛋白I(Tnl) ,B型钠尿肽 (BNP)等指标之间有无相关性。方法　采用微粒增强免疫透射比浊法定量检测了 5 5例健康体检者 ,5 0例隐匿型冠心病患者及4 6例急性心肌梗死患者的血清hs -CRP ,并同时检测其它几项心梗指标 ,并进行比较分析及相关分析。结果　 (1)隐匿型冠心病组、急性心肌梗死组血清超敏C -反应蛋白 (hs -CRP) ,CK ,CK -MB ,Tnl及BNP的结果与健康对照组相比较 ,均有显著性升高 (P <0 . 0 5 ) ;而冠心病患者中 ,急性心肌梗死组比隐匿型冠心病组的各项指标也有显著性的升高 (P <0. 0 5 )。 (2 )隐匿型冠心病患者及急性心梗患者的血清超敏C -反应蛋白与其他心梗指标进行相关性分析 ,结果表明血清hs-CRP与CK、CK -MB及Tnl之间具有良好的正相关 (P <0. 0 1) ,与BNP无明显相关性 ;CK、CK -MB、Tnl与BNP之间也具有良好的正相关 (P <0 .0 5 )。结论　血清超敏CRP(hs-CRP)可作为临床预测冠心病患者发生急性心梗危险性的指标 ,并可与CK、CK -MB、Tnl及BNP一起作为急性心梗的预后监测及疗效观察的指标。

The Correlation Study between Serum Hs-CRP and AMI Indexes in Acute Myocardial Infarction Patients

Objective To analyse the correlation between serum high-sensitivity C-reactive protein (hs-CRP) and acute myocardial infarction(AMI) indexes including CK, CK-MB, troponin I(Tn I), brain natriuretic peptide(BNP) in patients with latent cornary heart disease(CHD) and AMI. Method Serum hs-CRP was measured by particle enhanced immunoturbidimetric assay in 55 healthy persons, 50 patients with latent CHD and 46 AMI patients, the AMI indexes were also tested at the same time. Results (1) Compared with healthy people, the levels of serum hs-CRP, CK, CK-MB, Tnl and plasma BNP were significantly higher in patients with latent CHD and AMI(P<0 05) and above levels were higher in AMI patients than in patients with latent CHD(P<0 05);(2) In patients with latent CHD and AMI, significant positive correlation was found between serum hs-CRP and CK, CK-MB, Tnl (P<0 01); significant positive correlation between plasma BNP and serum CK, CK-MB, Tnl was also found (P>0 05), however, there was no correlation between serum hs-CRP and plasma BNP (P>0 05). Conclusions Serum hs-CRP can be served as a predictor of AMI, it is also a valuable index along with CK, CK-MB, Tnl and BNP for prognosis monitoring and curative effect.