1,2—二氯乙烷中毒性脑病脑水肿类型的实验研究

目的 为研究１，２－二氯乙烷中毒性脑病的脑水肿的类型。方法 以１，２－二氯乙烷为毒物，浓度为６００－８８０００ｍｇ／ｍ＾３，用动式吸入法对ＳＤ大鼠和ＮＩＨ小鼠染毒研制动物模型，后用１０００ｍｇ／ｍ＾３浓度，每天１０ｈ，连续染毒三天，复制ＳＤ大鼠中毒模型，以病理学的光镜和电镜检查为指标，研究其脑水肿类型。

Experimental study on types of brain edema induced by 1,2dichloroethane

Objective To study the types of brain edema induced by 1,2dichloroethane(DCE). Methods An inhalation experiment with DCE at 60088 000 mg/m3 was conducted to build up an animal intoxication model. In another experiment, SD rats were exposed to DCE via inhalation at 1 000 mg/m3, 10 hours per day for 3 days to study the types of brain edema which were classified by the pathological changes with both light and electronic microscopies. Results The intoxication models could be formed (60%) in rats under those conditions: 900 mg/m3, 10 hours per day for 5 days; 1 000 mg/m3, 10 hours per day for 3 days; or 1 800 mg/m3, 10 hours per day for 2 days. The similar result (20%) could be seen in NIH mice at 1 000 mg/m3, 10 hours per day for 3 days. CNS pathological changes included edema, hemorrhage and necrosis, among them, edema was the most obvious change. In the brain edema models, the occurence of nervous fibrosis seemed to be earlier and more serious, with certain but lighter changes in neurons. Conclusion The types of DCE intoxicated brain edema were first shown as vasogenic and then expressed mainly as mixed brain edema.