镉对大鼠雌性性腺毒性研究

目的　镉的雌性性腺生殖毒性研究颇少见。本文通过亚慢性镉染毒，观察了镉对大鼠的雌性性腺毒性。方法　随机将动物分四组，染镉剂量分别为１ 、０－５ 、０－２５ 和０ ｍｇ／ｋｇ 体重。腹腔注射染毒，每日一次，每周５ 天，连续６ 周。结果　镉染毒各剂量组大鼠卵巢镉含量均显著高于对照组；高、中剂量染毒组大鼠动情周期均比对照组显著延长；高、中剂量染毒组大鼠闭锁卵泡构成比显著高于对照组。结论　卵巢同肾脏一样，也是镉的重要的靶器官之一。镉的雌性性腺生殖毒性可表现为动情周期的明显延长，卵巢细胞生长发育过程的明显障碍

Toxic effect of cadmium on the female rat gonad

Objective Due to lack of previous works, subchronic cadmium effect on the female gonad was carried out. Methods Rats were divided into four groups with cadmium daily dose 1, 0 5, 0 25, and 0 mg/kg respectively,five days a week, up to six weeks Results The cadmium content in the ovary was significantly higher in exposed rats than in control rats The estrous cycle was delayed and the proportion of atresic follicle was also significantly increased in exposed rats Conclusion The ovary, like the kidney seemed to be one of the important target organs of cadmium The effect of cadmium on the female gonad was shown to have the extrous cycle delayed and the proportion of atresic follicle increased