冠心病家族史可预测非乙醇性脂肪肝的发生

目的: 研究高血压、冠心病、糖尿病家族史与非乙醇性脂肪肝(NAFLD)之间的联系. 方法: 健康职员202例均无过量饮酒史,无HBV及HCV病毒感染的证据. 脂肪肝的诊断根据肝脏超声结果判定. 结果:在202例受试者中发现NAFLD 68例(34%). 回归分析显示冠心病家族史增加NAFLD的发病风险(OR=2.25,P=0.014),高血压和糖尿病家族史对NAFLD的发病无影响. 冠心病家族史增加多项代谢异常(中心性肥胖、高甘油三酯血症、高血压)而导致NAFLD的发生. 结论:冠心病家族史是NAFLD发生的重要因素.

Family history of coronary heart disease as an important predictor for nonalcoholic fatty liver disease

AIM: To explore the relationship between family history of coronary heart disease (CHD), hypertension, and diabetes with nonalcoholic fatty liver disease (NAFLD). METHODS: Two hundred and two healthy office workers with no evidence of excessive alcohol drinking or hepatitis B or C virus infection were enrolled in the present study performed from March to June in 2004, and underwent liver ultrasound examination for diagnosing NAFLD. RESULTS: NAFLD was identified in 68 subjects (33.7%) by abdominal ultrasound. Logistic regression analysis showed that the presence of CHD family history increased the risk of NAFLD by 2.25-fold (P=0.014), while family history of diabetes or hypertension did not increased the risk. In combination with the presence of a family history of CHD, the effect on odds ratios (ORs) was increased for several metabolic features in predicting the incidence of NAFLD, including increased waist circumference (OR=3.548, 95%CI: 1.895- 6.643, P<0.001 vs OR=3.512, 95%CI: 1.831-6.737, P<0.001), hypertriglyceridemia (OR=4.549, 95%CI: 2.380-8.695, P<0.001 vs OR=4.012, 95%CI: 2.295-8.481, P<0.001), hypertension (OR=2.038, 95%CI: 1.065-3.899, P=0.031 vs OR=1.633, 95%CI: 0.820-3.251, P= 0.163), and the occurrence of the metabolic syndrome (OR= 4.505, 95%CI: 2.032-9.986, P<0.001 vs OR=4.347, 95%CI: 1.834-10.300, P=0.001). CONCLUSION: CHD family history is an important risk factor for the occurrence of NAFLD.