Pathophysiology of Myocardial Infarction |
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Authors: | Andreas Skyschally Rainer Schulz Prof. Dr. Dr. h. c. Gerd Heusch FRCP |
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Affiliation: | Institute of Pathophysiology,West German Heart Center, UniversityHospital Essen, Germany. |
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Abstract: | One or several short cycles of ischemia/reperfusion before (preconditioning) or after (postconditioning) a sustained coronary occlusion with subsequent reperfusion reduce the ultimate infarct size. The protection is potent, but limited to a narrow time frame. In animal experiments, a complex signal transduction cascade was identified which results specifically in a reduction of reperfusion injury. There is evidence for both ischemic pre- and postconditioning in patients with coronary artery disease. |
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