| 氨固酮和慢心律对房室传导影响的比较 |
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| 引用本文： | 肖继皋,李选德,刘天培.氨固酮和慢心律对房室传导影响的比较[J].南京医科大学学报,1986(2). |
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| 作者姓名： | 肖继皋 李选德 刘天培 |
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| 作者单位： | 南京医学院药理学教研室
(肖继皋，李选德)，南京医学院药理学教研室(刘天培) |
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| 摘 要： | 左心插管法记录麻醉家兔希氏束电图(HBE)和ECG,静脉注射(iv)氨固酮(4.0,5.6,8.0,11.2和16mg/kg)和慢心律(2.5,3.5,5.0,7.0和10.0mg/kg)都有剂量依赖的P-R,A-H和H-V时间的延长,氨固酮的作用较慢心律弱。两药延长P-R、A-H和H-V的回归系数并无显著差别(P>0.5)。氨固酮对房室传导的抑制可能系药物的直接作用。
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| 关 键 词： | 抗心律失常药/药效学 氨固酮/药效学 慢心律/药效学 希氏束/药物作用 心脏传导系统/药物作用 心电描记术 动物 兔 体外研究 对比研究 |
COMPARATIVE EFFECTS OF ORG 6001 AND MEXILETINE ON ATRIAL VENTRICULAR CONDUCTION |
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| Xiao Jigao.COMPARATIVE EFFECTS OF ORG 6001 AND MEXILETINE ON ATRIAL VENTRICULAR CONDUCTION[J].Acta Universitatis Medicinalis Nanjing,1986(2). |
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| Authors: | Xiao Jigao |
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| Abstract: | A depression of atrial-ventricular (A-V) conduction of Org 6001 wascompared with that of mexiletine. EigherOrg 6001 (4.0, 5.6, 8.0, 11.2 and 16mg/kg) or mexiletine (2.5, 3.5, 5.0,7.0 and 10.0 mg/kg) iv produced adose-dependent prolongation in P-R,A-H and H-V. The action of mexiletinewas more potent than that of Org 6001.No significant difference was ever notedbetween the two drugs in the regressioncoefficients of prolongation of P-R,A-H andH-V interval. Reserpinazationand vagotomy did not prevent theprolongation. These results suggest thatA-V supressive action of the two drugsis a direct one. |
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| Keywords: | Anti-arrhythmia agents/pharm Aminosteroid/Pharm Mexiletine/Phar Bundle of His/Drug eff Heart conduction system/Drug eff Animal Electrocardiography Rabbits In Vitro Comparative study |
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