| 基质金属蛋白酶-9在甲状腺肿瘤组织中的表达 |
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| 引用本文： | 李良毅,林玲,邱建龙. 基质金属蛋白酶-9在甲状腺肿瘤组织中的表达[J]. 福建医药杂志, 2012, 34(4): 85-86 |
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| 作者姓名： | 李良毅 林玲 邱建龙 |
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| 作者单位： | 李良毅 (福建医科大学附属第二医院内分泌科,泉州,362000) ； 林玲 (福建医科大学附属第二医院内分泌科,泉州,362000) ； 邱建龙 (福建医科大学附属第二医院病理科,泉州,362000) ； |
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| 摘 要： | 目的探讨基质金属蛋白酶-9(MMP-9)在甲状腺肿瘤组织的表达情况。方法采用免疫组织化学SP法检测20例瘤旁甲状腺组织、20例甲状腺腺瘤和53例甲状腺癌的石蜡标本MMP-9表达水平。结果 MMP-9在甲状腺腺癌的表达率显著高于甲状腺腺瘤(96.41%vs 55%,P<0.01),瘤旁甲状腺组织未见表达。结论甲状腺肿瘤存在MMP-9的过表达。
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| 关 键 词： | 甲状腺肿瘤 MMP-9 免疫组织化学 |
Expression of matrix metalloproteinase-9 in thyroid tumors tissue |
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| LI Liang-yi,LIN Ling,QIU Jian-long. Expression of matrix metalloproteinase-9 in thyroid tumors tissue[J]. Fujian Medical Journal, 2012, 34(4): 85-86 |
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| Authors: | LI Liang-yi LIN Ling QIU Jian-long |
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| Affiliation: | .Department of Endocrinology,the Second Affiliated Hospital,Fujian Medical University,Quanzhou,Fujian 362000,China |
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| Abstract: | Objective To investigate the expression of matrix metalloproteinase-9(MMP-9) in thyroid tumors tissues.Methods Immunohistochemistry was applied to examine the expression of MMP-9 in 20 cases of adjacent tumor tissue,20 cases of thyroid adenomas and 53 cases of thyroid carcinomas.All the specimens were paraffin-embedded.Results The expression of MMP-9 was not detected in adjacent tumor tissue.The expression of MMP-9 was significantly different between thyroid carcinomas and thyroid adenomas(96.41% vs 55.0%,P<0.01).Conclusion MMP-9 is over-expression in thyroid tumors and it will be useful for the diagnosis of thyroid carcinoma. |
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| Keywords: | thyroid tumors MMP-9 immunohistochemistry |
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