| 不同糖耐量者血清丙二醛及超氧化物歧化酶水平的变化 |
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| 引用本文： | 王丽宏,艾静,张巾超,李强,杨梅,杨宝峰.不同糖耐量者血清丙二醛及超氧化物歧化酶水平的变化[J].中国实用内科杂志,2005,25(4):311-312. |
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| 作者姓名： | 王丽宏 艾静 张巾超 李强 杨梅 杨宝峰 |
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| 作者单位： | 1. 哈尔滨医科大学附属第二医院内分泌科,150086
2. 哈尔滨医科大学药理教研室 |
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| 摘 要： | 目的 分析不同糖耐量时氧化应激的变化及其与胰岛素抵抗(IR)的关系。方法 2003-05 ~12哈尔滨医科大学附属第二医院测正常人、肥胖、糖耐量减低(IGT)和新诊断2型糖尿病(T2DM)患者血清丙二醛(MDA)及超氧化物歧化酶(SOD)水平,分析两指标与胰岛素敏感指数(ISI)的关系。结果 肥胖组和IGT组已存在氧化应激。MDA与ISI呈显著负相关,SOD与ISI呈显著正相关(均P<0.01)。结论 T2DM患者IR可能与氧化应激有关。
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| 关 键 词： | 氧化应激 胰岛素抵抗 |
| 文章编号： | 1005-2194(2005)04-0311-02 |
| 修稿时间： | 2004年12月10 |
Serum superoxide dismutase level and malondiadehyde level in subjects with different glucose tolerance |
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| Wang Lihong ,Ai Jing,Zhang Jinchao,et al..Serum superoxide dismutase level and malondiadehyde level in subjects with different glucose tolerance[J].Chinese Journal of Practical Internal Medicine,2005,25(4):311-312. |
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| Authors: | Wang Lihong Ai Jing Zhang Jinchao |
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| Institution: | Wang Lihong *,Ai Jing,Zhang Jinchao,et al. * Depa rtment of Endocrinology,The Second Affiliated Hospital to Harbin Medical Univers ity,Harbin 150086,China |
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| Abstract: | Objective To investigate the state of oxidative s tr ess in patients with different glucose tolerance and the relationship between ox idative stress and insulin resistance(IR).Methods The levels of serum superoxide dismutase (SOD) and malo ndiadehyde(MDA)were measured in subjects of controls,obesity,impaired glucose to lerance (IGT) and newly diagnosed type 2 diabetes mellitus(T2DM).Results Oxidative stress has already existed in obesity and IGT group.MDA level was negatively correlated with insulin sensitive index (ISI) an d SOD level was positively correlated with ISI(all P<0.01).Conclusion Oxidative stress may play a role in the deveopment o f insulin resistance in T2DM. |
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| Keywords: | Oxidative stress Insulin resistance |
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