Impact of age on myocardial uptake of 123I-mIBG in older adult subjects without coronary heart disease |
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Authors: | Arnold F Jacobson MD PhD Ji Chen PhD Liudmilla Verdes MD Russell D Folks BS Daya N Manatunga MS Ernest V Garcia PhD |
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Institution: | 1. Medical Diagnostics, GE Healthcare, 101 Carnegie Center, Princeton, NJ, 08540, USA 2. Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA
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Abstract: | Background The purpose of this study was to examine the relationship between myocardial uptake of 123I-mIBG and age in older normal adult subjects. Methods 94 subjects (age 29-82, mean 58.5) without coronary heart disease were studied. All subjects underwent early and delayed planar and 4-hour SPECT 123I-mIBG imaging. 123I-mIBG uptake was quantified as heart/mediastinum ratio on planar images (H/M p) and on SPECT images (H/M s) reconstructed by filtered backprojection, ordered subsets-expectation maximization (OSEM), and OSEM with compensation for collimator septal penetration (DSP). Relationships between age and 123I-mIBG uptake were examined by correlation analysis, t-tests, and analysis of variance. Results There was no significant correlation between age and H/M p, reflecting comparable increases in activity in the two regions of interest with age. Results on SPECT analyses were comparable, with no significant correlation between age and H/M s. Using DSP, 123I-mIBG H/M s was significantly higher in subjects ≥70 of age compared with younger subjects. Conclusions Both cardiac and background uptake of 123I-mIBG increase with age in older subjects without coronary heart disease, resulting in stability of H/M results (planar and SPECT). This study suggests that prognostic analyses of quantitative 123I-mIBG uptake in patients with heart disease do not require adjustment for patient age. |
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